Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3358233..3360070 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name hipA Uniprot ID A0A5B8HPP8
Locus tag Dpoa569_RS15015 Protein ID WP_042872361.1
Coordinates 3358724..3360070 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag Dpoa569_RS15010 Protein ID WP_050569498.1
Coordinates 3358233..3358727 (-) Length 165 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS14985 3353558..3354397 - 840 WP_042872353.1 MurR/RpiR family transcriptional regulator -
Dpoa569_RS14990 3354558..3356147 + 1590 WP_146411504.1 gamma-glutamyltransferase family protein -
Dpoa569_RS14995 3356191..3356388 + 198 WP_042872355.1 oxalurate catabolism protein HpxX -
Dpoa569_RS15000 3356385..3357782 + 1398 WP_042872358.1 AtzE family amidohydrolase -
Dpoa569_RS15005 3357794..3358174 + 381 WP_042872359.1 oxalurate catabolism protein HpxZ -
Dpoa569_RS15010 3358233..3358727 - 495 WP_050569498.1 helix-turn-helix domain-containing protein Antitoxin
Dpoa569_RS15015 3358724..3360070 - 1347 WP_042872361.1 type II toxin-antitoxin system HipA family toxin Toxin
Dpoa569_RS15020 3360345..3361292 - 948 WP_042872371.1 allantoinase PuuE -
Dpoa569_RS15025 3361332..3362069 - 738 WP_042872383.1 allantoin racemase -
Dpoa569_RS15030 3362085..3362810 - 726 WP_042872388.1 GntR family transcriptional regulator -
Dpoa569_RS15035 3362964..3364448 + 1485 WP_042872389.1 NCS1 family nucleobase:cation symporter-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-389)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-141)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50444.07 Da        Isoelectric Point: 5.1022

>T135011 WP_042872361.1 NZ_CP042220:c3360070-3358724 [Dickeya poaceiphila]
MERLTVQAFVDNVWQDIAEIGFPDSDQNNYLLTRLDYASDYGIDYIDCDDHHAVSVNYPVRVFFDDGGEPGWMRFLDDIM
PAGASRQYWIDHLDLSGLPAQLQNYVLLRHATIAPVGNLRIKESVPARHHGKTRFFSIEDVKNRASDFLDYAQQRGAAAG
GATGAGGEAPKLLLRCHADDKVWIDTWQDDPNCCDAAYLVKFPRGQRSEIDGDILRAEFHYYHELAYMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGNGQVKRYGMESVYSLLRAGPGSALRHDQVIRAVIAKIASSHTVSVEGKFFDPEAFVVEWV
RRDLLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFERIAELFSDILPPTLL
MAKLQETAVQLVGLKARLQARGVPESIVNLPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

>T135011 NZ_CP042220:c3360070-3358724 [Dickeya poaceiphila]
ATGGAGCGACTGACTGTTCAGGCGTTTGTCGATAATGTGTGGCAGGATATTGCCGAGATCGGTTTTCCTGATAGCGACCA
GAATAATTACCTGCTAACGCGGCTGGATTATGCGTCTGATTATGGCATTGACTATATAGATTGTGATGACCACCACGCGG
TTTCCGTCAATTACCCGGTCCGGGTCTTCTTTGATGATGGTGGTGAACCCGGATGGATGCGCTTTCTGGATGACATTATG
CCGGCAGGCGCCAGCCGACAGTATTGGATTGATCATCTTGATCTCTCTGGGTTGCCGGCACAGTTGCAAAATTATGTCTT
GTTGCGCCATGCCACCATTGCACCGGTTGGTAATTTGCGTATCAAAGAATCAGTTCCAGCCCGACATCATGGTAAAACCC
GCTTTTTCAGCATTGAGGATGTGAAGAACCGGGCCAGCGATTTTCTGGATTATGCGCAACAACGTGGTGCCGCTGCCGGA
GGGGCTACAGGTGCGGGAGGTGAAGCGCCAAAGCTGCTGTTGCGATGTCATGCGGACGATAAGGTATGGATCGATACCTG
GCAGGATGATCCCAACTGTTGTGATGCCGCTTATCTGGTGAAGTTTCCGCGTGGGCAGCGCAGTGAGATTGACGGCGACA
TCCTGCGAGCCGAGTTTCATTATTACCATGAGCTGGCCTATATGGGGTTCGACACCATTCCTGTGGCGGGTATGCGCCTG
GAAGAAGGACGGCATTATCCGTCGCTCTGGTTGCCGCGCTTTGATATCGAATTCCCCGGCAATGGACAGGTTAAACGATA
CGGTATGGAGTCGGTGTATTCCCTGCTGCGGGCCGGGCCGGGTAGTGCGCTGCGGCACGATCAGGTGATTCGGGCGGTGA
TCGCCAAAATCGCGTCCAGTCATACGGTTAGCGTAGAGGGAAAATTTTTTGACCCTGAGGCGTTTGTGGTTGAGTGGGTG
CGACGCGATCTGTTGAATATTGCCTTCGGCAACAGTGATAACCATGGTCGCAATACCGCGTTTCTCAAAGATGAACAGGG
GATTCGGTTGGCACCGATTTACGATTTTGCACCGATGAAGGCTGACCCCGCGGGCATTGCCAGAGCGACCAAATGGCCGG
AGCCGCTGGAAATCGGCGGTGACTATCAGTTTGAGCGGATAGCGGAACTGTTTTCCGACATTCTTCCGCCGACGTTGTTG
ATGGCGAAATTGCAGGAGACAGCGGTGCAACTGGTTGGTCTGAAAGCGCGGCTTCAGGCACGTGGCGTACCTGAGTCGAT
AGTAAACCTGCCTTCCATCGGGTTTGATTACCTTCCTGAGAAGCTACAGCGCTGGGGATTGTTATGA

Antitoxin


Download         Length: 165 a.a.        Molecular weight: 18260.07 Da        Isoelectric Point: 10.7653

>AT135011 WP_050569498.1 NZ_CP042220:c3358727-3358233 [Dickeya poaceiphila]
MSQERKNITRYAVADDVQETIRKLRQRLQESNVAQERFQALPVVVTTGTADVSKTRASKNSRPLNASERQFAMQNIIRRM
MIGEISQGNALKELRLTVLGLKQDAYANLVGVSRKTLSEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATT
PASR

Download         Length: 495 bp

>AT135011 NZ_CP042220:c3358727-3358233 [Dickeya poaceiphila]
ATGAGCCAGGAACGCAAAAATATAACGCGCTACGCGGTTGCGGATGATGTTCAGGAAACCATACGCAAGCTGCGCCAGCG
CTTGCAGGAGAGCAATGTGGCGCAGGAGCGCTTTCAGGCTCTACCCGTAGTTGTAACTACGGGGACGGCGGATGTCTCGA
AAACGAGAGCATCAAAAAATTCCAGACCGCTCAATGCCAGCGAAAGGCAGTTTGCGATGCAGAACATTATCCGCAGGATG
ATGATAGGCGAAATATCGCAGGGAAACGCACTGAAAGAATTGCGCCTTACCGTGCTGGGTCTTAAGCAGGATGCTTATGC
CAATCTGGTTGGCGTATCACGTAAAACGTTGTCGGAAATAGAGAATGACAAAGGCAATTACACGGCGGATATCATCAACA
AAGTGTTTAAGCCTTTCGGTCTGAAGATGGGGCTTATTCCGGTATCGCCTTCATTACTGGCCGAGATACTCGCCACGACT
CCCGCCTCCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8HPP8

Antitoxin

Source ID Structure

References