Detailed information of TA system TA135010

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3303376..3304078
• Replicon: chromosome
• Accession: NZ_CP042220
• Organism: Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A5B8HPI0
• Locus tag: Dpoa569_RS14730
• Protein ID: WP_042868920.1
• Coordinates: 3303376..3303696 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: Dpoa569_RS14735
• Protein ID: WP_042873794.1
• Coordinates: 3303722..3304078 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Dpoa569_RS14710	3299211..3300530	+	1320	WP_042868928.1	site-specific integrase	-
Dpoa569_RS14715	3300610..3301659	-	1050	WP_042868926.1	macro domain-containing protein	-
Dpoa569_RS14720	3301673..3302320	-	648	WP_042868924.1	DUF4433 domain-containing protein	-
Dpoa569_RS14725	3302425..3303258	-	834	WP_042868922.1	DUF4942 domain-containing protein	-
Dpoa569_RS14730	3303376..3303696	-	321	WP_042868920.1	TA system toxin CbtA family protein	Toxin
Dpoa569_RS14735	3303722..3304078	-	357	WP_042873794.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
Dpoa569_RS14740	3304123..3304596	-	474	WP_042868918.1	DNA repair protein RadC	-
Dpoa569_RS14745	3304670..3305137	-	468	WP_050569398.1	hypothetical protein	-
Dpoa569_RS14750	3305166..3305732	-	567	WP_042868916.1	hypothetical protein	-
Dpoa569_RS14755	3305800..3306510	-	711	WP_042868914.1	transcriptional regulator	-
Dpoa569_RS14760	3306712..3307545	-	834	WP_042868912.1	DUF945 domain-containing protein	-
Dpoa569_RS14765	3307632..3308498	-	867	WP_042868910.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3282887..3305732	22845

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12071.76 Da
• Isoelectric Point: 4.7671

>T135010 WP_042868920.1 NZ_CP042220:c3303696-3303376 [Dickeya poaceiphila]
MQTPYPSPAREASSCLSPVNVWQQLLTYLLDKHYGLTLNDTPFCEEAEIQAYLDAGISLPDAVNFLVERYELVRIDRSGF
SWQEQKPFLNAVDILRARRATGLLKP

Nucleotide

• Length: 321 bp

>T135010 NZ_CP042220:c3303696-3303376 [Dickeya poaceiphila]
ATGCAAACACCATACCCATCCCCGGCGCGGGAGGCATCGTCATGCCTGTCACCTGTAAATGTCTGGCAACAGTTATTAAC
TTACCTGCTGGACAAGCACTACGGGCTGACGCTAAACGACACGCCGTTTTGTGAAGAAGCCGAGATCCAGGCCTACCTCG
ACGCCGGGATCTCGCTGCCGGACGCCGTGAACTTTCTGGTGGAGCGCTATGAGCTGGTGCGCATCGACCGCAGCGGTTTT
AGCTGGCAGGAGCAAAAACCGTTTCTGAACGCGGTCGATATTCTCCGCGCCAGACGCGCCACCGGCCTGCTCAAACCATA
A

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12984.78 Da
• Isoelectric Point: 6.6297

>AT135010 WP_042873794.1 NZ_CP042220:c3304078-3303722 [Dickeya poaceiphila]
MSLSDAPEWGLEHTLRPRFGARLVQEGCRLHFLADRAGVTGTFSATVACHLEHRFPLIVKQLEQKLVTGELDPYRQQRVT
LHDGVLTCEADTLGSAGYVYITIYPTTAATPTTAFPSP

Nucleotide

• Length: 357 bp

>AT135010 NZ_CP042220:c3304078-3303722 [Dickeya poaceiphila]
TTGTCATTATCGGATGCCCCGGAATGGGGACTTGAACACACCCTGAGACCGCGCTTTGGAGCCCGGCTGGTACAGGAGGG
GTGTCGCCTGCATTTTCTCGCCGACCGTGCCGGTGTGACCGGCACTTTCAGTGCAACCGTGGCCTGCCATCTGGAACACC
GCTTCCCATTGATAGTGAAACAACTGGAGCAAAAGCTTGTGACCGGTGAGCTCGATCCCTACCGACAGCAACGCGTCACG
CTGCATGACGGCGTACTGACCTGCGAGGCCGATACCCTGGGTAGTGCTGGCTACGTCTATATCACGATTTACCCGACCAC
GGCGGCCACACCGACAACCGCATTCCCTTCACCTTAA

Structures

Toxin

• AlphaFold DB: A0A5B8HPI0