Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3005526..3006151 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag Dpoa569_RS13340 Protein ID WP_009114000.1
Coordinates 3005948..3006151 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A5B8I8R0
Locus tag Dpoa569_RS13335 Protein ID WP_042869322.1
Coordinates 3005526..3005894 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS13320 3001287..3004433 + 3147 WP_146411447.1 efflux RND transporter permease subunit -
Dpoa569_RS13325 3004613..3004864 + 252 WP_042869325.1 type B 50S ribosomal protein L31 -
Dpoa569_RS13330 3004880..3005023 + 144 WP_012770724.1 type B 50S ribosomal protein L36 -
Dpoa569_RS13335 3005526..3005894 + 369 WP_042869322.1 Hha toxicity modulator TomB Antitoxin
Dpoa569_RS13340 3005948..3006151 + 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
Dpoa569_RS13350 3006738..3007064 + 327 WP_071604286.1 MGMT family protein -
Dpoa569_RS13355 3007090..3007647 - 558 WP_042869320.1 YbaY family lipoprotein -
Dpoa569_RS13360 3007881..3008744 + 864 WP_042869318.1 acyl-CoA thioesterase II -
Dpoa569_RS13365 3008839..3010131 - 1293 WP_042869316.1 ammonium transporter AmtB -
Dpoa569_RS13370 3010175..3010513 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T135009 WP_009114000.1 NZ_CP042220:3005948-3006151 [Dickeya poaceiphila]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T135009 NZ_CP042220:3005948-3006151 [Dickeya poaceiphila]
ATGAAAAAAATCGACTATCTAATGCGTTTGCGTAAATGCACAACCATCGATACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGATGAACTTGAAATGTTCTATTCAGCCGCAGACCACCGTCTTGCAGAGTTAACGATGAATAAAC
TTTACGACAAAGTACCAACTGCTGTGTGGAAATATGTTCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14239.11 Da        Isoelectric Point: 5.1811

>AT135009 WP_042869322.1 NZ_CP042220:3005526-3005894 [Dickeya poaceiphila]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSNRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT135009 NZ_CP042220:3005526-3005894 [Dickeya poaceiphila]
ATGGATGAGTATACACCCCAACATTATGATATTGCCCAACTCAGATTCTTATGTGAAAATCTGCACGATGAAAGTATTGC
TACATTAGGTGACAGTAACCGTGGATGGGTGAATGATCCGACCTCTGCGGTTAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCAGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGTTATGTGAACGAGTTGAGAAATATCTA
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATGCAGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A5B8I8R0

References