Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2627940..2628571 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name hicA Uniprot ID A0A5B8I7S7
Locus tag Dpoa569_RS11650 Protein ID WP_042869830.1
Coordinates 2627940..2628215 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5B8I6A2
Locus tag Dpoa569_RS11655 Protein ID WP_042869828.1
Coordinates 2628212..2628571 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS11630 2623049..2624293 - 1245 WP_042869839.1 MFS transporter -
Dpoa569_RS11635 2624363..2625454 - 1092 WP_071604292.1 4-oxalomesaconate tautomerase -
Dpoa569_RS11640 2625615..2626541 + 927 WP_042869835.1 LysR family transcriptional regulator -
Dpoa569_RS11645 2626731..2627786 + 1056 WP_042869833.1 MBL fold metallo-hydrolase -
Dpoa569_RS11650 2627940..2628215 + 276 WP_042869830.1 type II toxin-antitoxin system HicA family toxin Toxin
Dpoa569_RS11655 2628212..2628571 + 360 WP_042869828.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Dpoa569_RS11660 2628660..2628792 + 133 Protein_2275 type II toxin-antitoxin system HicB family antitoxin -
Dpoa569_RS11665 2628872..2629495 - 624 WP_042869826.1 RraA family protein -
Dpoa569_RS11670 2629590..2630399 - 810 WP_042869823.1 ABC transporter ATP-binding protein -
Dpoa569_RS11675 2630411..2631460 - 1050 WP_128569700.1 iron ABC transporter permease -
Dpoa569_RS11680 2631453..2632475 - 1023 WP_042869821.1 iron ABC transporter permease -
Dpoa569_RS11685 2632472..2633389 - 918 WP_042869819.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2620598..2628921 8323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-88)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10149.68 Da        Isoelectric Point: 10.6115

>T135007 WP_042869830.1 NZ_CP042220:2627940-2628215 [Dickeya poaceiphila]
MKEHVSSLRKRQKNTLEQVFKSPVQSGIKWVDIESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVANL
RDWLESIGVKP

Download         Length: 276 bp

>T135007 NZ_CP042220:2627940-2628215 [Dickeya poaceiphila]
ATGAAAGAACACGTCTCATCATTACGCAAGAGGCAAAAAAACACGCTTGAACAGGTGTTTAAATCTCCTGTTCAGTCAGG
TATCAAATGGGTGGATATCGAGTCACTGATAAAAGCGCTGGGAGGGGAAGTCAAAGAGGGCCGAGGTTCGCGTTGTAAGT
TTCTCCTTAATGGCAGTATCGCCAACTTTCATCGCCCACACCCTTCACCAGATACGGATAAAGGCGCAGTAGCCAACCTG
CGCGACTGGCTTGAAAGCATAGGAGTGAAGCCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13199.87 Da        Isoelectric Point: 4.9151

>AT135007 WP_042869828.1 NZ_CP042220:2628212-2628571 [Dickeya poaceiphila]
MSKLSAPNTIEIAGQPAVISYVPELGAFRGKFLGLTGYCDFVSDSIQGLKKEGEISLHEYLDDCSASGIEPYTRQEKIKT
FTLRYPESFGERLNQAAAEHDVSVNSFIIETLNERIKHA

Download         Length: 360 bp

>AT135007 NZ_CP042220:2628212-2628571 [Dickeya poaceiphila]
ATGAGCAAACTATCTGCACCAAACACGATTGAAATAGCTGGACAACCGGCTGTTATCAGCTATGTGCCGGAACTTGGCGC
ATTTCGTGGCAAGTTTCTTGGTCTGACTGGCTATTGTGATTTTGTATCGGACAGCATTCAAGGGCTGAAAAAAGAAGGTG
AGATTTCACTACATGAATATCTGGATGACTGTAGTGCATCAGGTATCGAGCCTTACACTCGGCAAGAAAAAATTAAGACG
TTCACACTGCGTTATCCTGAATCATTTGGCGAACGTTTAAATCAGGCCGCCGCTGAGCATGACGTTTCTGTGAACTCATT
CATTATTGAGACACTTAATGAGAGAATAAAACACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8I7S7

Antitoxin

Source ID Structure
AlphaFold DB A0A5B8I6A2

References