Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1917338..1917933 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name doc Uniprot ID A0A5B8I5Y5
Locus tag Dpoa569_RS08570 Protein ID WP_042870829.1
Coordinates 1917556..1917933 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A5B8I4C8
Locus tag Dpoa569_RS08565 Protein ID WP_042870831.1
Coordinates 1917338..1917559 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS08545 1912733..1914292 + 1560 WP_042870839.1 nitrate reductase subunit beta -
Dpoa569_RS08550 1914289..1915008 + 720 WP_042870837.1 nitrate reductase molybdenum cofactor assembly chaperone -
Dpoa569_RS08555 1915008..1915685 + 678 WP_042870835.1 respiratory nitrate reductase subunit gamma -
Dpoa569_RS08560 1916054..1917202 + 1149 WP_042870833.1 L-threonine dehydrogenase -
Dpoa569_RS08565 1917338..1917559 + 222 WP_042870831.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Dpoa569_RS08570 1917556..1917933 + 378 WP_042870829.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
Dpoa569_RS08575 1918101..1918838 - 738 WP_050569451.1 2OG-Fe(II) oxygenase -
Dpoa569_RS08580 1918865..1920100 - 1236 WP_042870826.1 MFS transporter -
Dpoa569_RS08585 1920097..1921104 - 1008 WP_042870824.1 glutathione synthase -
Dpoa569_RS08590 1921111..1922418 - 1308 WP_042870822.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1917338..1925730 8392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14239.33 Da        Isoelectric Point: 6.7251

>T134998 WP_042870829.1 NZ_CP042220:1917556-1917933 [Dickeya poaceiphila]
MKWVSAQDVIAFHDRILQMLPGVAGMADPGRAEALIYRVQNRLYYEDVTDLFVLAATYWVTVARGHIFNDGNKRTAFFVT
MVFLHRNGVLIADNDNSLEELTVKAATGEYQVSYLAEQLRLRVTR

Download         Length: 378 bp

>T134998 NZ_CP042220:1917556-1917933 [Dickeya poaceiphila]
ATGAAATGGGTCAGTGCACAGGACGTCATTGCTTTTCATGATCGCATTCTGCAGATGTTGCCAGGGGTTGCCGGTATGGC
AGATCCAGGTCGGGCGGAAGCCTTGATTTATCGGGTGCAGAACCGTCTTTATTATGAAGATGTGACGGATCTCTTTGTAC
TGGCGGCGACATATTGGGTAACTGTTGCGCGTGGTCACATCTTTAATGACGGTAATAAGCGCACCGCCTTTTTTGTCACC
ATGGTGTTTTTGCACCGTAATGGCGTATTGATTGCTGATAACGACAATTCGCTGGAAGAATTGACCGTTAAAGCGGCAAC
GGGTGAATATCAGGTGTCATATCTCGCGGAGCAGTTAAGGCTAAGAGTGACAAGGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.35 Da        Isoelectric Point: 6.7241

>AT134998 WP_042870831.1 NZ_CP042220:1917338-1917559 [Dickeya poaceiphila]
MKTYTITEARQHIATVIDTAASGEPVEITRRNGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHEHTVKALADR

Download         Length: 222 bp

>AT134998 NZ_CP042220:1917338-1917559 [Dickeya poaceiphila]
ATGAAAACGTACACCATTACTGAAGCTCGACAACATATTGCAACGGTCATTGATACGGCAGCCAGCGGTGAACCGGTGGA
AATTACGCGCCGCAATGGGACGTCGGCTGTGCTCATCCCCAAGGCCGAATTCGAGGCTTATCAAAAAGCCAGATTAGACG
CTGAATTTGATTTCATCATGCAGCGCCATGAACACACGGTCAAAGCGCTTGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8I5Y5

Antitoxin

Source ID Structure
AlphaFold DB A0A5B8I4C8

References