Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1142441..1144307 Replicon chromosome
Accession NZ_CP042219
Organism Pandoraea pnomenusa strain TF-18

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FP568_RS05285 Protein ID WP_145863116.1
Coordinates 1142441..1143367 (+) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FP568_RS05290 Protein ID WP_191239962.1
Coordinates 1143369..1144307 (+) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP568_RS05260 1137784..1138860 + 1077 WP_031627377.1 porin -
FP568_RS05265 1139186..1140055 + 870 WP_145863114.1 ABC transporter ATP-binding protein -
FP568_RS05270 1140096..1140878 + 783 WP_023597214.1 ABC transporter permease -
FP568_RS05275 1140895..1141686 + 792 WP_145863115.1 SDR family oxidoreductase -
FP568_RS05280 1141745..1142302 + 558 WP_023597212.1 cupin domain-containing protein -
FP568_RS05285 1142441..1143367 + 927 WP_145863116.1 alpha/beta fold hydrolase Toxin
FP568_RS05290 1143369..1144307 + 939 WP_191239962.1 IclR family transcriptional regulator Antitoxin
FP568_RS05295 1144304..1145110 + 807 WP_145863117.1 SDR family oxidoreductase -
FP568_RS05300 1145103..1146755 + 1653 WP_145863118.1 thiamine pyrophosphate-binding protein -
FP568_RS05305 1146748..1147566 + 819 WP_145863119.1 aspartate dehydrogenase -
FP568_RS05310 1147580..1149076 + 1497 WP_145863120.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, C-terminal

(167-290)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31526.62 Da        Isoelectric Point: 5.9367

>T134995 WP_145863116.1 NZ_CP042219:1142441-1143367 [Pandoraea pnomenusa]
MQAQANSSEVSEVSEVSADADVAALCARLAAFPYRTVTTRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALGLARVALAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYT
AAKAGPVAVAVGAQDGVTPPASCQTIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T134995 NZ_CP042219:1142441-1143367 [Pandoraea pnomenusa]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGAAGTGTCCGCGGACGCCGATGTCGCCGCCCTGTGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCACCACGCGCGCGGGCACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCGGTGGTGATGCTGCACGGCATCGGGTCGGGAGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTATGCCGACGCCCTCGAAGCGTGGCTCGATGCGCTCGGTCTTGCGCGCGTGGCGCTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCCGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAT
GGCAAGGCCGACCCGGCAGTACGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACACG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCAGGACGGCGTCACCCCTCCCGCGAGCTGCCAGACGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCATGCGTCATACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTCGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33967.73 Da        Isoelectric Point: 6.0582

>AT134995 WP_191239962.1 NZ_CP042219:1143369-1144307 [Pandoraea pnomenusa]
MAPANPKRAVAAASIDDSTQDVQDMQDTLDDEIAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT134995 NZ_CP042219:1143369-1144307 [Pandoraea pnomenusa]
ATGGCACCCGCCAATCCGAAGCGCGCCGTCGCCGCGGCGTCGATCGACGACAGCACGCAGGACGTGCAGGACATGCAGGA
CACGCTGGACGACGAAATCGCCGAGGCGGCGCCCGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACATCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCTGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAGCGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATCAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References