Detailed information of TA system TA134971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3893676..3894559
• Replicon: chromosome
• Accession: NZ_CP042180
• Organism: Pseudomonas sp. KBS0802

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q88K57
• Locus tag: FFH79_RS18400
• Protein ID: WP_003250527.1
• Coordinates: 3893676..3894113 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: I7C3Q7
• Locus tag: FFH79_RS18405
• Protein ID: WP_003250525.1
• Coordinates: 3894110..3894559 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFH79_RS18375	3889220..3889609	-	390	WP_049587628.1	hypothetical protein	-
FFH79_RS18380	3889612..3889860	-	249	Protein_3525	PAAR domain-containing protein	-
FFH79_RS18385	3890024..3891253	-	1230	WP_049587623.1	acyl-CoA dehydrogenase	-
FFH79_RS18390	3891394..3892320	+	927	WP_010953387.1	LysR family transcriptional regulator	-
FFH79_RS18395	3892514..3893668	+	1155	WP_049587669.1	aminotransferase class V-fold PLP-dependent enzyme	-
FFH79_RS18400	3893676..3894113	-	438	WP_003250527.1	RES family NAD+ phosphorylase	Toxin
FFH79_RS18405	3894110..3894559	-	450	WP_003250525.1	DUF2384 domain-containing protein	Antitoxin
FFH79_RS18410	3894702..3895355	-	654	WP_010953384.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
FFH79_RS18415	3895459..3896382	+	924	WP_010953383.1	LysR family transcriptional regulator	-
FFH79_RS18420	3896431..3897261	+	831	WP_003250518.1	AraC family transcriptional regulator	-
FFH79_RS18425	3897312..3897896	+	585	WP_010953382.1	LysE family transporter	-
FFH79_RS18430	3897936..3899135	-	1200	WP_049587621.1	sugar transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-138)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (33-91)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15990.29 Da
• Isoelectric Point: 5.6007

>T134971 WP_003250527.1 NZ_CP042180:c3894113-3893676 [Pseudomonas sp. KBS0802]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDCSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Nucleotide

• Length: 438 bp

>T134971 NZ_CP042180:c3894113-3893676 [Pseudomonas sp. KBS0802]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGTCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCTGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCTACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCTCAGCCTGAGTTGACCCGAACGCTGGGCAATCGCTTTCTGGATGACTGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACGCCGGACAGCCGCCTGTTCTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16956.46 Da
• Isoelectric Point: 5.7258

>AT134971 WP_003250525.1 NZ_CP042180:c3894559-3894110 [Pseudomonas sp. KBS0802]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Nucleotide

• Length: 450 bp

>AT134971 NZ_CP042180:c3894559-3894110 [Pseudomonas sp. KBS0802]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCCTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGCGATTTCGAAATCCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGTGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAACGCTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Structures

Toxin

• PDB: 6GW6

Antitoxin

• AlphaFold DB: I7C3Q7