Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 3827557..3828110 Replicon chromosome
Accession NZ_CP042180
Organism Pseudomonas sp. KBS0802

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag FFH79_RS18020 Protein ID WP_010953434.1
Coordinates 3827557..3827850 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag FFH79_RS18025 Protein ID WP_010953433.1
Coordinates 3827838..3828110 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFH79_RS17990 3822711..3823229 - 519 WP_049587643.1 DUF1993 domain-containing protein -
FFH79_RS30150 3823372..3823584 - 213 WP_061405625.1 hypothetical protein -
FFH79_RS18000 3823581..3823790 - 210 WP_010953438.1 4-oxalocrotonate tautomerase family protein -
FFH79_RS18005 3823860..3824591 - 732 WP_010953437.1 SDR family oxidoreductase -
FFH79_RS18010 3824705..3825631 + 927 WP_010953436.1 LysR family transcriptional regulator -
FFH79_RS18015 3826154..3827563 + 1410 WP_010953435.1 site-specific integrase -
FFH79_RS18020 3827557..3827850 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFH79_RS18025 3827838..3828110 - 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
FFH79_RS18030 3828235..3828480 - 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FFH79_RS18035 3828742..3829014 + 273 WP_031299398.1 hypothetical protein -
FFH79_RS18040 3829112..3830080 + 969 WP_031299399.1 DUF932 domain-containing protein -
FFH79_RS18045 3830160..3831164 + 1005 WP_010953429.1 YqaJ viral recombinase family protein -
FFH79_RS18050 3831257..3832207 + 951 WP_031299400.1 hypothetical protein -
FFH79_RS18055 3832179..3832538 + 360 Protein_3463 DNA repair protein RadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T134970 WP_010953434.1 NZ_CP042180:c3827850-3827557 [Pseudomonas sp. KBS0802]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T134970 NZ_CP042180:c3827850-3827557 [Pseudomonas sp. KBS0802]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT134970 WP_010953433.1 NZ_CP042180:c3828110-3827838 [Pseudomonas sp. KBS0802]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT134970 NZ_CP042180:c3828110-3827838 [Pseudomonas sp. KBS0802]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References