Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 2241546..2242135 | Replicon | chromosome |
| Accession | NZ_CP042180 | ||
| Organism | Pseudomonas sp. KBS0802 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q88G26 |
| Locus tag | FFH79_RS10490 | Protein ID | WP_010954726.1 |
| Coordinates | 2241546..2241794 (+) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A2V4F1F2 |
| Locus tag | FFH79_RS10495 | Protein ID | WP_049587764.1 |
| Coordinates | 2241794..2242135 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FFH79_RS10435 | 2237011..2237394 | - | 384 | WP_010954737.1 | hypothetical protein | - |
| FFH79_RS10440 | 2237409..2237960 | - | 552 | WP_049587760.1 | hypothetical protein | - |
| FFH79_RS10445 | 2238067..2238345 | + | 279 | WP_010954735.1 | hypothetical protein | - |
| FFH79_RS10450 | 2238359..2238709 | - | 351 | WP_010954734.1 | hypothetical protein | - |
| FFH79_RS10455 | 2238791..2239249 | - | 459 | WP_010954733.1 | hypothetical protein | - |
| FFH79_RS10460 | 2239246..2239515 | - | 270 | WP_010954732.1 | hypothetical protein | - |
| FFH79_RS10465 | 2239535..2239918 | - | 384 | WP_049587761.1 | helix-turn-helix transcriptional regulator | - |
| FFH79_RS10475 | 2240555..2240764 | - | 210 | WP_049587762.1 | hypothetical protein | - |
| FFH79_RS10485 | 2241136..2241396 | - | 261 | WP_010954727.1 | DUF1654 domain-containing protein | - |
| FFH79_RS10490 | 2241546..2241794 | + | 249 | WP_010954726.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| FFH79_RS10495 | 2241794..2242135 | + | 342 | WP_049587764.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| FFH79_RS10500 | 2242303..2242869 | - | 567 | WP_049587766.1 | hypothetical protein | - |
| FFH79_RS10505 | 2242872..2243864 | - | 993 | WP_049587768.1 | hypothetical protein | - |
| FFH79_RS10510 | 2244031..2244267 | - | 237 | WP_010954724.1 | hypothetical protein | - |
| FFH79_RS10515 | 2244311..2244724 | - | 414 | WP_010954723.1 | HIRAN domain-containing protein | - |
| FFH79_RS10520 | 2244782..2245429 | - | 648 | WP_010954722.1 | helix-turn-helix transcriptional regulator | - |
| FFH79_RS10525 | 2245517..2245729 | + | 213 | WP_010954721.1 | helix-turn-helix domain-containing protein | - |
| FFH79_RS10530 | 2246054..2246884 | + | 831 | WP_010954720.1 | replication protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2228429..2279548 | 51119 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9137.67 Da Isoelectric Point: 10.4156
>T134969 WP_010954726.1 NZ_CP042180:2241546-2241794 [Pseudomonas sp. KBS0802]
MSKQEKLLAKLLNKQAGFTWPELVTLLGGLGYRHIEGDGSRVKFDNGHPQAMINLHKPHPGNELKAYVKRQVIEHLKAGG
LI
MSKQEKLLAKLLNKQAGFTWPELVTLLGGLGYRHIEGDGSRVKFDNGHPQAMINLHKPHPGNELKAYVKRQVIEHLKAGG
LI
Download Length: 249 bp
>T134969 NZ_CP042180:2241546-2241794 [Pseudomonas sp. KBS0802]
ATGTCTAAGCAAGAAAAGCTGCTCGCGAAGCTGCTGAACAAGCAAGCAGGATTCACTTGGCCTGAGCTGGTCACGCTGCT
GGGTGGGCTTGGATACCGCCATATCGAGGGTGATGGCAGCCGAGTGAAGTTCGACAATGGCCACCCGCAGGCAATGATCA
ACTTGCACAAGCCGCACCCCGGCAATGAGCTGAAGGCCTACGTTAAACGCCAGGTAATAGAGCACCTGAAAGCAGGAGGA
TTGATCTGA
ATGTCTAAGCAAGAAAAGCTGCTCGCGAAGCTGCTGAACAAGCAAGCAGGATTCACTTGGCCTGAGCTGGTCACGCTGCT
GGGTGGGCTTGGATACCGCCATATCGAGGGTGATGGCAGCCGAGTGAAGTTCGACAATGGCCACCCGCAGGCAATGATCA
ACTTGCACAAGCCGCACCCCGGCAATGAGCTGAAGGCCTACGTTAAACGCCAGGTAATAGAGCACCTGAAAGCAGGAGGA
TTGATCTGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12402.90 Da Isoelectric Point: 5.0719
>AT134969 WP_049587764.1 NZ_CP042180:2241794-2242135 [Pseudomonas sp. KBS0802]
MSTMLQYRGYYGSIEASPEDNCLFGKLQFIRALVSYEGETVAELTQAFRDAVDDYLDTCASLGQNPEIPCKGSFNVRVGH
DLHLAASVAATKQSISLNDLTRKALSEYLGHHA
MSTMLQYRGYYGSIEASPEDNCLFGKLQFIRALVSYEGETVAELTQAFRDAVDDYLDTCASLGQNPEIPCKGSFNVRVGH
DLHLAASVAATKQSISLNDLTRKALSEYLGHHA
Download Length: 342 bp
>AT134969 NZ_CP042180:2241794-2242135 [Pseudomonas sp. KBS0802]
ATGAGCACCATGTTGCAGTACCGAGGCTACTACGGCTCCATTGAGGCCAGCCCCGAGGACAATTGCCTATTCGGCAAGCT
TCAGTTCATCCGCGCCCTTGTCAGCTATGAGGGCGAGACGGTTGCTGAACTGACCCAGGCGTTCCGCGATGCAGTGGACG
ACTATCTCGACACCTGCGCATCACTCGGGCAGAACCCGGAAATTCCGTGCAAGGGGTCGTTCAATGTGAGGGTAGGGCAC
GACCTGCACCTAGCGGCCAGCGTGGCAGCCACCAAGCAAAGTATTTCCTTGAATGATCTGACACGCAAAGCGCTTAGTGA
GTACCTGGGTCATCACGCGTAG
ATGAGCACCATGTTGCAGTACCGAGGCTACTACGGCTCCATTGAGGCCAGCCCCGAGGACAATTGCCTATTCGGCAAGCT
TCAGTTCATCCGCGCCCTTGTCAGCTATGAGGGCGAGACGGTTGCTGAACTGACCCAGGCGTTCCGCGATGCAGTGGACG
ACTATCTCGACACCTGCGCATCACTCGGGCAGAACCCGGAAATTCCGTGCAAGGGGTCGTTCAATGTGAGGGTAGGGCAC
GACCTGCACCTAGCGGCCAGCGTGGCAGCCACCAAGCAAAGTATTTCCTTGAATGATCTGACACGCAAAGCGCTTAGTGA
GTACCTGGGTCATCACGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q88G26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2V4F1F2 |