Detailed information of TA system TA134962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1819136..1819782
• Replicon: chromosome
• Accession: NZ_CP042178
• Organism: Burkholderia sp. KBS0801

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FFI87_RS24980
• Protein ID: WP_138848650.1
• Coordinates: 1819136..1819543 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q0BA09
• Locus tag: FFI87_RS24985
• Protein ID: WP_011658485.1
• Coordinates: 1819540..1819782 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFI87_RS24960	1814925..1815509	-	585	WP_138848654.1	hypothetical protein	-
FFI87_RS24965	1815506..1816246	-	741	WP_138848653.1	chemotaxis protein	-
FFI87_RS24970	1816249..1818639	-	2391	WP_138848652.1	MCP four helix bundle domain-containing protein	-
FFI87_RS24980	1819136..1819543	-	408	WP_138848650.1	type II toxin-antitoxin system VapC family toxin	Toxin
FFI87_RS24985	1819540..1819782	-	243	WP_011658485.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FFI87_RS24990	1820045..1820734	+	690	WP_138848649.1	phospholipase	-
FFI87_RS24995	1820778..1822271	-	1494	WP_138848648.1	amino acid permease	-
FFI87_RS25000	1822375..1823781	-	1407	WP_012365787.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14840.87 Da
• Isoelectric Point: 6.0877

>T134962 WP_138848650.1 NZ_CP042178:c1819543-1819136 [Burkholderia sp. KBS0801]
MKFLLDTNAVIAILKGEQAMLARLRSHQPADFGIPAIVAHELYYGAYKSQRAAANLARVEGLQFEVVSFDAEDAQHAGEI
RAQLAAVGTPIGPYDALIAGQARARRLVLVTHNTREFERVSELQVEDWLAAAREN

Nucleotide

• Length: 408 bp

>T134962 NZ_CP042178:c1819543-1819136 [Burkholderia sp. KBS0801]
ATGAAATTTCTGCTGGATACCAACGCGGTAATCGCGATTCTGAAAGGCGAACAGGCCATGCTGGCCCGATTGCGTAGCCA
TCAACCTGCGGATTTCGGAATTCCCGCGATCGTCGCGCATGAACTCTATTACGGGGCGTACAAGAGTCAGAGAGCGGCAG
CGAATCTGGCACGCGTCGAGGGGCTTCAGTTCGAGGTCGTGTCGTTCGATGCGGAAGATGCTCAGCATGCCGGGGAAATC
CGTGCGCAACTGGCCGCGGTGGGAACACCGATCGGGCCATACGATGCATTGATCGCAGGACAGGCGCGAGCGCGACGCCT
GGTGCTTGTCACGCACAACACGCGCGAGTTTGAGCGGGTCTCGGAGCTGCAGGTCGAGGATTGGCTCGCGGCGGCGCGCG
AAAACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8872.03 Da
• Isoelectric Point: 4.7628

>AT134962 WP_011658485.1 NZ_CP042178:c1819782-1819540 [Burkholderia sp. KBS0801]
METAKIFKHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAAATEPAAQERPGLDVFE

Nucleotide

• Length: 243 bp

>AT134962 NZ_CP042178:c1819782-1819540 [Burkholderia sp. KBS0801]
ATGGAGACTGCCAAGATTTTCAAGCATGGTGGATCGCAGGCCGTCCGCTTGCCGAAGGATTTCCGCTTCGATACCACGGA
GGTCCGGATTCGTCGGCACGGCGCGTCTGTCATTCTCGAACCGGTGCCGCAAGACTGGGCATGGCTGACACCGTTGATCG
GCCCGGTTGACGCCGATTTCGAGGCCGCCGCGGCAACCGAGCCTGCCGCTCAAGAGCGTCCAGGGCTGGACGTGTTTGAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A3P0NDJ4