Detailed information of TA system TA134961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 1456168..1456801
• Replicon: chromosome
• Accession: NZ_CP042178
• Organism: Burkholderia sp. KBS0801

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FFI87_RS23400
• Protein ID: WP_138848850.1
• Coordinates: 1456168..1456581 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B1YWM2
• Locus tag: FFI87_RS23405
• Protein ID: WP_012366057.1
• Coordinates: 1456568..1456801 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFI87_RS23380	1451652..1452779	-	1128	WP_012366060.1	VOC family protein	-
FFI87_RS23390	1453133..1454440	+	1308	WP_138848852.1	shikimate transporter	-
FFI87_RS23395	1454651..1455952	+	1302	WP_138848851.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FFI87_RS23400	1456168..1456581	-	414	WP_138848850.1	PIN domain-containing protein	Toxin
FFI87_RS23405	1456568..1456801	-	234	WP_012366057.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FFI87_RS23410	1456959..1457729	+	771	WP_012366056.1	helix-turn-helix domain-containing protein	-
FFI87_RS23415	1457769..1460069	-	2301	WP_138848849.1	ATP-dependent DNA helicase	-
FFI87_RS23420	1460066..1461757	-	1692	WP_138848848.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (10-119)

Antitoxin

• SpoVT-AbrB domain (5-37)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15313.48 Da
• Isoelectric Point: 4.9378

>T134961 WP_138848850.1 NZ_CP042178:c1456581-1456168 [Burkholderia sp. KBS0801]
MSGIEPAKSFVDSNVVLYLLSEDETKANRAEALFLRRPTISVQVLNEVASVCSHKLRMPWSDIGQFLEPIRSLCQVVPIT
VDTHDLARRLAERHGFSFYDACIVATASIEGCEYLYTEDMHDGLRVEGGPVLRNPFA

Nucleotide

• Length: 414 bp

>T134961 NZ_CP042178:c1456581-1456168 [Burkholderia sp. KBS0801]
ATGAGCGGGATTGAGCCGGCGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGAGGACGAGACCAAGGC
GAATCGTGCGGAGGCGCTGTTCCTTCGGCGGCCGACCATCAGCGTTCAGGTACTCAACGAAGTTGCCAGCGTTTGCAGCC
ACAAATTGCGCATGCCGTGGAGCGACATAGGGCAGTTTCTGGAGCCGATCAGGAGTTTGTGCCAGGTCGTCCCGATCACG
GTGGACACGCATGACCTGGCGCGAAGGCTGGCGGAGCGGCACGGTTTCTCTTTCTACGACGCGTGCATCGTGGCAACCGC
TTCGATCGAGGGCTGCGAATACCTGTACACGGAGGACATGCACGACGGCTTGCGCGTGGAGGGTGGTCCGGTGTTGCGAA
ATCCGTTTGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8835.07 Da
• Isoelectric Point: 8.8306

>AT134961 WP_012366057.1 NZ_CP042178:c1456801-1456568 [Burkholderia sp. KBS0801]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLQRLRRFRGKLPADFKFSRDDANERD

Nucleotide

• Length: 234 bp

>AT134961 NZ_CP042178:c1456801-1456568 [Burkholderia sp. KBS0801]
ATGCAGGTTGCAAAGTGGGGCAATAGCCTGGCGGTCCGCCTGCCGGCCAGCGTGGTCGATGCACTCGAGCTCCGCGAGGG
AGACGACATCGAAATCGTGGTTGACAGCCCCCGCGTTTTCGCGGTGAGCCGCAAGCCGCGGCCCGACGAACTTCTGCAGC
GGTTGAGGCGTTTCCGGGGCAAGCTGCCCGCTGACTTCAAGTTCAGCCGGGACGACGCAAATGAGCGGGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A3N7ZAY4