Detailed information of TA system TA134960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1313113..1313752
• Replicon: chromosome
• Accession: NZ_CP042178
• Organism: Burkholderia sp. KBS0801

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FFI87_RS22810
• Protein ID: WP_186381761.1
• Coordinates: 1313336..1313752 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q0B8R6
• Locus tag: FFI87_RS22805
• Protein ID: WP_006753828.1
• Coordinates: 1313113..1313349 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFI87_RS22790	1308609..1309478	+	870	WP_138848928.1	LysR family transcriptional regulator	-
FFI87_RS22795	1310205..1311431	-	1227	WP_138848927.1	acyltransferase	-
FFI87_RS22800	1311659..1312861	+	1203	WP_138848926.1	DUF2029 domain-containing protein	-
FFI87_RS22805	1313113..1313349	+	237	WP_006753828.1	DNA-binding protein	Antitoxin
FFI87_RS22810	1313336..1313752	+	417	WP_186381761.1	type II toxin-antitoxin system VapC family toxin	Toxin
FFI87_RS22815	1313974..1314255	+	282	Protein_1156	biphenyl 2,3-dioxygenase	-
FFI87_RS22820	1314255..1314449	+	195	Protein_1157	3-ketosteroid-9-alpha-hydroxylase	-
FFI87_RS22825	1314784..1314987	+	204	WP_006751843.1	cold-shock protein	-
FFI87_RS22830	1315449..1315712	+	264	WP_006751842.1	translation initiation factor IF-1	-
FFI87_RS22835	1316006..1316116	-	111	Protein_1160	4-hydroxy-2-oxovalerate aldolase	-
FFI87_RS22840	1316151..1316360	+	210	Protein_1161	electron transfer flavoprotein subunit alpha/FixB family protein	-
FFI87_RS22845	1316364..1316879	+	516	WP_138848924.1	transferase hexapeptide repeat family protein	-
FFI87_RS22850	1317191..1317439	+	249	WP_012366135.1	hypothetical protein	-
FFI87_RS22855	1317463..1318626	-	1164	WP_138848923.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15251.48 Da
• Isoelectric Point: 7.4701

>T134960 WP_186381761.1 NZ_CP042178:1313336-1313752 [Burkholderia sp. KBS0801]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAAADASPLYLSIVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYASNI
LPVDIETAQMWGHLRVPDPAHALDHLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T134960 NZ_CP042178:1313336-1313752 [Burkholderia sp. KBS0801]
GTGTTTTTGATTGATACGAACGTCATCAGCGAGATCAGAAAGGGCAAGCGAACCAACCGCGGCGTGCGCGCATTCTTCAG
GCAGGCGGCGGCCGACGCGAGCCCGCTTTACCTGTCGATCGTGACGGTGGCCGAACTGCGGCGCGGCGTCGACCTGATCC
GTCATCGCGGCGATCACCCGCAGGCGTCGGCGCTCGAGGCATGGATGGCGACGATCCTGTCCGGCTATGCGTCGAACATC
CTGCCGGTCGATATCGAGACCGCCCAGATGTGGGGCCATTTGCGCGTGCCCGATCCGGCCCATGCCCTCGACCACCTGAT
CGCGGCCACCGCGCTGATCAACGATCTGACGGTCGTCACCCGCAATGTCGACGATTTCGCTCGCACCGGCGTCCGGCTGC
TGAACCCGTTCGATTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8682.73 Da
• Isoelectric Point: 5.0774

>AT134960 WP_006753828.1 NZ_CP042178:1313113-1313349 [Burkholderia sp. KBS0801]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT134960 NZ_CP042178:1313113-1313349 [Burkholderia sp. KBS0801]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCCGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGACGGACATTCGCGCAAGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KQ31