Detailed information of TA system TA134958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 919941..920596
• Replicon: chromosome
• Accession: NZ_CP042178
• Organism: Burkholderia sp. KBS0801

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B1YY30
• Locus tag: FFI87_RS21015
• Protein ID: WP_012366457.1
• Coordinates: 920177..920596 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FFI87_RS21010
• Protein ID: WP_138850213.1
• Coordinates: 919941..920180 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFI87_RS20990	915227..915700	-	474	WP_138849239.1	hypothetical protein	-
FFI87_RS20995	915935..916618	-	684	WP_138849237.1	Fe2+-dependent dioxygenase	-
FFI87_RS21000	916615..917370	-	756	WP_138849235.1	sel1 repeat family protein	-
FFI87_RS21005	917374..919617	-	2244	WP_138849233.1	TonB-dependent siderophore receptor	-
FFI87_RS21010	919941..920180	+	240	WP_138850213.1	Arc family DNA-binding protein	Antitoxin
FFI87_RS21015	920177..920596	+	420	WP_012366457.1	type II toxin-antitoxin system VapC family toxin	Toxin
FFI87_RS21020	920733..922028	-	1296	WP_012366456.1	aspartate carbamoyltransferase	-
FFI87_RS21025	922264..922398	+	135	WP_011659177.1	entericidin A/B family lipoprotein	-
FFI87_RS21030	922498..923070	-	573	WP_138849231.1	permease	-
FFI87_RS21035	923196..924155	-	960	WP_138849229.1	DMT family transporter	-
FFI87_RS21040	924414..925208	-	795	WP_138849227.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-44)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15003.27 Da
• Isoelectric Point: 5.8793

>T134958 WP_012366457.1 NZ_CP042178:920177-920596 [Burkholderia sp. KBS0801]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYASLCAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAR

Nucleotide

• Length: 420 bp

>T134958 NZ_CP042178:920177-920596 [Burkholderia sp. KBS0801]
ATGATCCTCGTCGATACCAACGTTATTTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAATGGCTCGATGC
GCAGAATGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAAATGCGTTTCGGCGTGGCCGCGTTGCCGGAAGGGA
GAAGGCGGGACTGGCTGCACCAAAGCATCGAGCAGCGCGTCGTGCCGCTGTTTCGCGGTCGGATCCTGCCGTTCGACGAT
GCGGCCAGTAAAGCCTATGCGAGCCTTTGTGCGAAGGCTCGTGCCACCGGCAACGCGATGGCGTCTGCCGATGGATTTAT
CGCTGCAACGGCCGCGGCGAACGGGTTGATCGTGGCGACGCGTGACGTCGCGCCGTTCGAAGCGGCGGGCTTGCGCGTGA
TCGACCCGTGGGCCCGGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8626.82 Da
• Isoelectric Point: 6.2196

>AT134958 WP_138850213.1 NZ_CP042178:919941-920180 [Burkholderia sp. KBS0801]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRAILEEAVRPTGRAKLGTLLADIGREAGGIDFEIPHVSSPTDPMSFE

Nucleotide

• Length: 240 bp

>AT134958 NZ_CP042178:919941-920180 [Burkholderia sp. KBS0801]
ATGCCGGTTATTACCGTTCGAAATTTGCCCGACGAGGTGCATCGCGCGCTTCGCATCCGTGCGGCGCAACATGGTCGGAG
CACCGAAGCGGAGGTGCGCGCCATCCTCGAGGAAGCCGTTCGGCCCACCGGCCGGGCGAAGCTGGGGACGCTGCTGGCTG
ATATCGGGCGGGAGGCGGGTGGTATCGATTTCGAGATTCCGCATGTGAGCTCGCCAACCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: B1YY30