Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 859279..859802 Replicon chromosome
Accession NZ_CP042178
Organism Burkholderia sp. KBS0801

Toxin (Protein)


Gene name relE Uniprot ID B1YYI4
Locus tag FFI87_RS20735 Protein ID WP_012366508.1
Coordinates 859279..859545 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1YYI3
Locus tag FFI87_RS20740 Protein ID WP_012366507.1
Coordinates 859542..859802 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFI87_RS20710 854455..855708 - 1254 WP_138849295.1 diaminopimelate decarboxylase -
FFI87_RS20715 855818..856732 + 915 WP_012366512.1 LysR family transcriptional regulator -
FFI87_RS20720 856831..857430 + 600 WP_138849293.1 GNAT family N-acetyltransferase -
FFI87_RS20725 857549..858121 - 573 WP_138849291.1 DUF4142 domain-containing protein -
FFI87_RS20730 858536..859159 - 624 WP_105830446.1 HAD hydrolase-like protein -
FFI87_RS20735 859279..859545 - 267 WP_012366508.1 Txe/YoeB family addiction module toxin Toxin
FFI87_RS20740 859542..859802 - 261 WP_012366507.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FFI87_RS20745 859955..860398 + 444 WP_138849289.1 GNAT family N-acetyltransferase -
FFI87_RS20750 860454..860672 + 219 WP_006751720.1 DUF1653 domain-containing protein -
FFI87_RS20755 860779..861990 - 1212 WP_138849287.1 winged helix-turn-helix domain-containing protein -
FFI87_RS20760 862340..863728 - 1389 WP_012366503.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10468.82 Da        Isoelectric Point: 8.8834

>T134957 WP_012366508.1 NZ_CP042178:c859545-859279 [Burkholderia sp. KBS0801]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYA

Download         Length: 267 bp

>T134957 NZ_CP042178:c859545-859279 [Burkholderia sp. KBS0801]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTACGTTTATTGGCAAGGGCAAGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAACGGACGCCGTTCGAAGGCATCGGCAAACCCGAACCGCTGAAGGCCA
ATCTGTCCGGTTTCTGGTCACGCCGCATCGACGATACGAACCGTCTCGTCTACGAAGCGGACGATCTTCAGATCAGCATC
GTGTCCTGCCGCTATCACTACGCGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9759.03 Da        Isoelectric Point: 6.0735

>AT134957 WP_012366507.1 NZ_CP042178:c859802-859542 [Burkholderia sp. KBS0801]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQEYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Download         Length: 261 bp

>AT134957 NZ_CP042178:c859802-859542 [Burkholderia sp. KBS0801]
ATGCGCACGATTCACTTTTCGGATGCCCGCGGCAATCTCAAGACGGTCATCGACCAGGTCGTCGACGACGCGGATGTGAC
GCTCATCACACGTCGCGACGCGCCGAACGCCGTCATCATGTCGCAGGAATACTACGACAGCCTGATGGAGACGGTTCACC
TGCTCCGCTCGCCGGCCAACGTCGCCCACCTCGAACGCTCGATCGCGCAATTGCGCAAGGGCAAGGCGAAAGAGCACAAG
CTGGCGGAGGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A102EVD7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9KUE4

References