Detailed information of TA system TA134956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 720721..721968
• Replicon: chromosome
• Accession: NZ_CP042178
• Organism: Burkholderia sp. KBS0801

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FFI87_RS20080
• Protein ID: WP_138849378.1
• Coordinates: 720721..721302 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FFI87_RS20085
• Protein ID: WP_012366623.1
• Coordinates: 721411..721968 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFI87_RS20060	716021..716812	+	792	WP_138849382.1	enoyl-CoA hydratase	-
FFI87_RS20065	716809..717948	+	1140	WP_138849381.1	enoyl-CoA hydratase/isomerase family protein	-
FFI87_RS20070	717991..718926	-	936	WP_138849380.1	LysR family transcriptional regulator	-
FFI87_RS20075	719104..720642	+	1539	WP_138849379.1	MFS transporter	-
FFI87_RS20080	720721..721302	-	582	WP_138849378.1	HD domain-containing protein	Toxin
FFI87_RS20085	721411..721968	-	558	WP_012366623.1	helix-turn-helix domain-containing protein	Antitoxin
FFI87_RS20090	722040..722687	-	648	WP_138849377.1	hypothetical protein	-
FFI87_RS20095	723050..724453	+	1404	WP_138849376.1	DUF308 domain-containing protein	-
FFI87_RS20100	724625..725356	+	732	WP_138849375.1	ribonuclease T2	-
FFI87_RS20105	725444..726079	-	636	WP_138849374.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (8-149)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21515.05 Da
• Isoelectric Point: 4.9807

>T134956 WP_138849378.1 NZ_CP042178:c721302-720721 [Burkholderia sp. KBS0801]
MNLDTIHARLDFLREAERLKDVLRSGHTSTGRRESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRALRDEIVALWDEYEAAESREARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDATPLFGAIRAIVDADTQRRIDARGDGA

Nucleotide

• Length: 582 bp

>T134956 NZ_CP042178:c721302-720721 [Burkholderia sp. KBS0801]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
TACGTCGACGGGCCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGTCTCTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGACGTCGACACGACGAAGCTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCGGACAAGAGCACGCACGAACGCGACGACCTGCTGACGCTGACGGCCGGGCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGAATCGCGGGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGACGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGACGCGGACACGCAACGCCGGATCGA
CGCACGCGGCGACGGCGCGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20226.20 Da
• Isoelectric Point: 11.0874

>AT134956 WP_012366623.1 NZ_CP042178:c721968-721411 [Burkholderia sp. KBS0801]
MTTSPLHTPPLGPQLKRWRALRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPSRAAEFSRPLPALLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGTNASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT134956 NZ_CP042178:c721968-721411 [Burkholderia sp. KBS0801]
ATGACGACCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTTGCCGCGCGTCTCGATTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCCAGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCTCACGCATCGGCTGCTCGCCTGCTCGCCGTCGCGGGCGGCGGAGTTCTC
GCGGCCGCTGCCGGCGTTGCTCGGTACCTCGCTATGGCGCTATGCGTCGCCGGAAATTGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGATCGCGCTGGGCCGCCGAGCGTCGAGTTCGCGACCGGCACCAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGTACCTGCCGGTGGACGCGCATGACGCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTAG