Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2553623..2554305 Replicon chromosome
Accession NZ_CP042177
Organism Burkholderia sp. KBS0801

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag FFI87_RS12145 Protein ID WP_175739552.1
Coordinates 2553623..2553985 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FFI87_RS12150 Protein ID WP_138847374.1
Coordinates 2553982..2554305 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFI87_RS12120 2549474..2549929 + 456 WP_138847378.1 VOC family protein -
FFI87_RS12125 2550013..2551563 - 1551 WP_012364381.1 sodium:solute symporter family protein -
FFI87_RS12130 2551560..2551802 - 243 WP_006754439.1 DUF3311 domain-containing protein -
FFI87_RS12135 2552001..2552918 - 918 WP_138847377.1 spermidine synthase -
FFI87_RS12140 2553064..2553318 + 255 WP_138847376.1 hypothetical protein -
FFI87_RS12145 2553623..2553985 + 363 WP_175739552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFI87_RS12150 2553982..2554305 + 324 WP_138847374.1 helix-turn-helix domain-containing protein Antitoxin
FFI87_RS12155 2554361..2554726 - 366 Protein_2266 DNA-deoxyinosine glycosylase -
FFI87_RS12160 2554885..2555700 - 816 WP_138847373.1 hypothetical protein -
FFI87_RS12165 2555955..2557856 - 1902 WP_186381700.1 DUF91 domain-containing protein -
FFI87_RS12170 2558235..2559209 - 975 WP_138848470.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2553623..2563794 10171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13289.12 Da        Isoelectric Point: 9.7472

>T134955 WP_175739552.1 NZ_CP042177:2553623-2553985 [Burkholderia sp. KBS0801]
MDPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGRKHDQAKPLRGFGSAGVLEIVESEDNGTYRAVYTVKLGNSV
YVLHCFQKKSSSGIATPKPDGDLVRERLKAAEAHAKGERR

Download         Length: 363 bp

>T134955 NZ_CP042177:2553623-2553985 [Burkholderia sp. KBS0801]
ATGGACCCGTACACCAAACCGCTCTACTGGCTCGGCTCAGCGCGCAAGGACCTGAAAGCCATGCCCGAAGCCGTGCAGGA
CACGTTCGGCTATGCACTGTATCTGGCCCAGACGGGACGCAAGCACGATCAGGCCAAGCCATTGAGAGGATTCGGATCGG
CCGGCGTGCTCGAGATCGTGGAATCGGAAGACAACGGCACGTACCGCGCCGTATACACAGTGAAACTCGGCAACAGCGTC
TACGTGCTGCACTGCTTTCAGAAGAAATCATCGAGCGGCATCGCGACACCCAAGCCGGACGGCGATCTGGTCCGCGAACG
TCTGAAAGCGGCCGAGGCTCACGCAAAAGGAGAAAGGCGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11908.83 Da        Isoelectric Point: 8.0427

>AT134955 WP_138847374.1 NZ_CP042177:2553982-2554305 [Burkholderia sp. KBS0801]
MIEIEQGSTNVYADLGMRDADEMRVKAQLAAKIAEIIKARKWTQQHAARLLGMTQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVQIVVGPDRQSDVEGHIEVVFAA

Download         Length: 324 bp

>AT134955 NZ_CP042177:2553982-2554305 [Burkholderia sp. KBS0801]
ATGATCGAAATCGAACAGGGCAGCACGAACGTCTACGCTGACCTGGGCATGCGCGATGCCGACGAAATGCGAGTGAAGGC
TCAACTCGCCGCGAAGATCGCGGAGATCATCAAGGCGCGCAAATGGACGCAGCAGCACGCGGCCCGGCTGCTCGGCATGA
CGCAGCCGAAACTGTCGAACATGCTGCGCGGGCAGTTTCGCGGCGTCAGCGAAACGAAGATGCTCGAATGTCTGGCGAAG
CTCGGACGCGACGTGCAAATTGTCGTCGGACCGGATCGTCAGTCGGACGTCGAAGGGCATATCGAAGTCGTATTCGCCGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References