Detailed information of TA system TA134954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1741376..1742061
• Replicon: chromosome
• Accession: NZ_CP042177
• Organism: Burkholderia sp. KBS0801

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: B1YQB5
• Locus tag: FFI87_RS08315
• Protein ID: WP_012363863.1
• Coordinates: 1741639..1742061 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B1YQB4
• Locus tag: FFI87_RS08310
• Protein ID: WP_012363862.1
• Coordinates: 1741376..1741642 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFI87_RS08295	1736894..1739155	+	2262	WP_138847738.1	TonB-dependent siderophore receptor	-
FFI87_RS08300	1739242..1740081	+	840	WP_012363860.1	folate-dependent phosphoribosylglycinamide formyltransferase PurN-like protein	-
FFI87_RS08305	1740081..1741097	+	1017	WP_138847737.1	acetyltransferase	-
FFI87_RS08310	1741376..1741642	+	267	WP_012363862.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FFI87_RS08315	1741639..1742061	+	423	WP_012363863.1	type II toxin-antitoxin system VapC family toxin	Toxin
FFI87_RS08320	1742104..1743009	-	906	WP_138847736.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
FFI87_RS08325	1742978..1744048	-	1071	WP_138847735.1	hypothetical protein	-
FFI87_RS08330	1744403..1745566	+	1164	WP_138847734.1	amidohydrolase	-
FFI87_RS08335	1745588..1746913	-	1326	WP_138847733.1	cobyrinate a,c-diamide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14774.90 Da
• Isoelectric Point: 7.8887

>T134954 WP_012363863.1 NZ_CP042177:1741639-1742061 [Burkholderia sp. KBS0801]
VTTLYMLDTNICSFIMRERPSAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGKKASPKHAELVTAFVSRLDGVLSWDTA
AVDATTAIRVDLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASV

Nucleotide

• Length: 423 bp

>T134954 NZ_CP042177:1741639-1742061 [Burkholderia sp. KBS0801]
GTGACGACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCATCCGCGGTGTTGTCCCGGTT
GCAGTCTTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCGATCACCTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
AAAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGGCTGGATGGCGTGCTGTCGTGGGATACCGCG
GCGGTCGATGCAACGACCGCGATTCGCGTCGACCTGGCCGCACGTGGCACGCCGATCGGCGCGAACGACGCGTCGATCGC
CGGTCACGCGATCGCGGCCGGTGCCGTGCTTGTAACGAACAACAGTCGCGAATTCAGCCGTGTCGCGGGGTTGTCGCTCG
AAGACTGGGCAGCCTCGGTCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10038.27 Da
• Isoelectric Point: 4.5626

>AT134954 WP_012363862.1 NZ_CP042177:1741376-1741642 [Burkholderia sp. KBS0801]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPHADADFLVERPAVVEPGRFDLPGADD
DARTESDR

Nucleotide

• Length: 267 bp

>AT134954 NZ_CP042177:1741376-1741642 [Burkholderia sp. KBS0801]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGTTGCTGCTGCGTCCGGTGCGGCCGACGTGGCTGTCGTTCGCGAGTGAAC
CACACGCCGATGCCGACTTCCTCGTCGAGCGCCCGGCGGTCGTCGAACCTGGTCGTTTCGACCTGCCCGGCGCCGATGAC
GATGCACGGACGGAGTCGGACCGGTGA

Structures

Toxin

• AlphaFold DB: B1YQB5

Antitoxin

• AlphaFold DB: B1YQB4