Detailed information of TA system TA134946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3290936..3291555
• Replicon: chromosome
• Accession: NZ_CP042173
• Organism: Yersinia sp. KBS0713

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: Q66DR5
• Locus tag: FFE93_RS15715
• Protein ID: WP_002208622.1
• Coordinates: 3291352..3291555 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: FFE93_RS15710
• Protein ID: WP_005272706.1
• Coordinates: 3290936..3291304 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFE93_RS15680	3286587..3286847	+	261	WP_049602348.1	type B 50S ribosomal protein L31	-
FFE93_RS15685	3286863..3287006	+	144	WP_002208618.1	type B 50S ribosomal protein L36	-
FFE93_RS15690	3287149..3288027	-	879	WP_049602347.1	metal ABC transporter substrate-binding protein	-
FFE93_RS15695	3288056..3288913	-	858	WP_032897187.1	metal ABC transporter permease	-
FFE93_RS15700	3288910..3289647	-	738	WP_049602345.1	ABC transporter ATP-binding protein	-
FFE93_RS15705	3290424..3290777	+	354	WP_005272705.1	hypothetical protein	-
FFE93_RS15710	3290936..3291304	+	369	WP_005272706.1	Hha toxicity modulator TomB	Antitoxin
FFE93_RS15715	3291352..3291555	+	204	WP_002208622.1	expression modulating protein YmoA	Toxin
FFE93_RS15725	3292449..3292754	+	306	WP_186367721.1	MGMT family protein	-
FFE93_RS15730	3292799..3293344	-	546	WP_138775476.1	YbaY family lipoprotein	-
FFE93_RS15735	3293601..3294461	+	861	WP_049602338.1	acyl-CoA thioesterase II	-
FFE93_RS15740	3294599..3295888	-	1290	WP_032897241.1	ammonium transporter AmtB	-
FFE93_RS15745	3295928..3296266	-	339	WP_002208627.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8063.31 Da
• Isoelectric Point: 6.4573

>T134946 WP_002208622.1 NZ_CP042173:3291352-3291555 [Yersinia sp. KBS0713]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Nucleotide

• Length: 204 bp

>T134946 NZ_CP042173:3291352-3291555 [Yersinia sp. KBS0713]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAGTGTACGACTATTGATACGCTAGAACGTGTAATTGAAAAGAATAA
GTACGAACTTTCCGACGATGAGTTGGAATTATTTTACTCAGCGGCTGATCATCGTCTGGCGGAACTCACAATGAATAAGC
TTTATGATAAAATTCCACCTACAGTTTGGCAGCATGTGAAATAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14218.98 Da
• Isoelectric Point: 4.4314

>AT134946 WP_005272706.1 NZ_CP042173:3290936-3291304 [Yersinia sp. KBS0713]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTAAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Nucleotide

• Length: 369 bp

>AT134946 NZ_CP042173:3290936-3291304 [Yersinia sp. KBS0713]
ATGGATGAGTACTCGCCTAAGCGGCATGATATTGCCCAGTTGAAGTTTCTCTGTGAGAGTTTGTATGATGAAGGCATTGC
TACGCTTGGTGATAGCCACCATGGGTGGGTCAATGACCCCACAGCAGCTGTAAATCTACAACTTAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTGTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTACGGGATCAATGATCCTGAATTGCGTCGCTGGCAAAAAACCAAAGAGCGGTT
ATTCAGACTTTTCTCAGGAGAATACATCTGTACCCTGATGAAAACTTAA

Structures

Toxin

• PDB: 2K5S