Detailed information of TA system TA134937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2475694..2476207
• Replicon: chromosome
• Accession: NZ_CP042173
• Organism: Yersinia sp. KBS0713

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A209AEM7
• Locus tag: FFE93_RS11640
• Protein ID: WP_012105238.1
• Coordinates: 2475923..2476207 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FFE93_RS11635
• Protein ID: WP_054872663.1
• Coordinates: 2475694..2475933 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFE93_RS11620	2471728..2472477	-	750	WP_138775229.1	phage head morphogenesis protein	-
FFE93_RS11625	2472536..2473921	-	1386	WP_138775162.1	DUF1073 domain-containing protein	-
FFE93_RS11630	2473924..2475567	-	1644	WP_138775163.1	phage terminase large subunit	-
FFE93_RS11635	2475694..2475933	+	240	WP_054872663.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FFE93_RS11640	2475923..2476207	+	285	WP_012105238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FFE93_RS11645	2476218..2477246	-	1029	WP_054872664.1	terminase small subunit	-
FFE93_RS11650	2477250..2477510	-	261	WP_138775230.1	hypothetical protein	-
FFE93_RS11655	2477513..2478127	-	615	WP_138775164.1	protein Mom	-
FFE93_RS11660	2478124..2478633	-	510	WP_138775165.1	ParB/Srx family N-terminal domain-containing protein	-
FFE93_RS11665	2479000..2479740	-	741	WP_138775166.1	protein phosphatase 2C domain-containing protein	-
FFE93_RS11670	2479737..2480537	-	801	WP_138775167.1	protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2449896..2501318	51422

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-74)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.99 Da
• Isoelectric Point: 10.3007

>T134937 WP_012105238.1 NZ_CP042173:2475923-2476207 [Yersinia sp. KBS0713]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREEAYSEAGKRV

Nucleotide

• Length: 285 bp

>T134937 NZ_CP042173:2475923-2476207 [Yersinia sp. KBS0713]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTGAAGGAATGGCATAAGCTCGGCGATACTGTACGTCAGCAATTTAA
GAAAAAGTTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGCTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAAGCGCGTTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8850.14 Da
• Isoelectric Point: 4.5105

>AT134937 WP_054872663.1 NZ_CP042173:2475694-2475933 [Yersinia sp. KBS0713]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAIVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT134937 NZ_CP042173:2475694-2475933 [Yersinia sp. KBS0713]
ATGGGTAACATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAACTGGGCGTCACCCC
CTCTGATTTGCTGCGCCAGACACTGGAATACGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCATAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A209AEM7