Detailed information of TA system TA134934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1327318..1327853
• Replicon: chromosome
• Accession: NZ_CP042173
• Organism: Yersinia sp. KBS0713

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FFE93_RS06135
• Protein ID: WP_138774914.1
• Coordinates: 1327566..1327853 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2G4U619
• Locus tag: FFE93_RS06130
• Protein ID: WP_032897508.1
• Coordinates: 1327318..1327569 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFE93_RS06105	1322702..1323205	+	504	WP_005273362.1	ferredoxin-type protein NapF	-
FFE93_RS06110	1323195..1323461	+	267	WP_032897496.1	chaperone NapD	-
FFE93_RS06115	1323458..1325953	+	2496	WP_032897499.1	nitrate reductase catalytic subunit NapA	-
FFE93_RS06120	1326076..1326543	+	468	WP_032897502.1	nitrate reductase cytochrome c-type subunit	-
FFE93_RS06125	1326585..1327184	+	600	WP_032897505.1	cytochrome c-type protein NapC	-
FFE93_RS06130	1327318..1327569	+	252	WP_032897508.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FFE93_RS06135	1327566..1327853	+	288	WP_138774914.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FFE93_RS06140	1327998..1328573	+	576	WP_005273377.1	GDP-mannose pyrophosphatase NudK	-
FFE93_RS06145	1328791..1331070	+	2280	WP_005273379.1	NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase	-
FFE93_RS06150	1331221..1331676	-	456	WP_032897515.1	YaiI/YqxD family protein	-
FFE93_RS06155	1331676..1332602	-	927	WP_005273381.1	oxygen-dependent coproporphyrinogen oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11283.24 Da
• Isoelectric Point: 10.3839

>T134934 WP_138774914.1 NZ_CP042173:1327566-1327853 [Yersinia sp. KBS0713]
MIYPVKFREEALKEWHKLDKTIQQQFAKKLKKCSDNPHTESARLRSMKNCYKIKLRSSGFRLVYEVIDDILIIAVVAVGK
RERNEVYQLASDRLR

Nucleotide

• Length: 288 bp

>T134934 NZ_CP042173:1327566-1327853 [Yersinia sp. KBS0713]
ATGATTTATCCCGTTAAATTCAGAGAAGAAGCGCTAAAGGAGTGGCACAAACTGGATAAGACGATACAGCAGCAGTTTGC
CAAGAAATTAAAAAAATGCAGCGATAATCCGCATACTGAAAGCGCAAGACTGCGCAGCATGAAAAATTGCTACAAAATTA
AATTACGATCTTCTGGATTTAGATTAGTGTATGAAGTTATCGATGATATTTTGATTATTGCAGTGGTTGCCGTAGGAAAA
AGAGAGCGCAATGAAGTTTATCAACTTGCAAGTGATAGATTACGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9190.40 Da
• Isoelectric Point: 4.3127

>AT134934 WP_032897508.1 NZ_CP042173:1327318-1327569 [Yersinia sp. KBS0713]
MPSVILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPAFYCVPAELYEQIMDALDDHELAKLVNERRNQSLHDIDLD
SYL

Nucleotide

• Length: 252 bp

>AT134934 NZ_CP042173:1327318-1327569 [Yersinia sp. KBS0713]
ATGCCAAGTGTGATTTTGACTGATACCAGCGCCAGTGTGAGTGAACTGAAGAAAAATCCAATGGCAACGGTCAATGCTGG
CGCGGGATTTCCTGTTGCCATTCTCAACCGCAATCAACCCGCTTTCTATTGCGTCCCCGCCGAACTTTACGAACAAATAA
TGGATGCACTCGATGATCATGAGCTAGCAAAACTGGTCAATGAGCGCCGTAATCAATCGTTGCATGATATCGATCTGGAC
AGCTATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2G4U619