Detailed information of TA system TA134933

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 941601..942276
• Replicon: chromosome
• Accession: NZ_CP042173
• Organism: Yersinia sp. KBS0713

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FFE93_RS04380
• Protein ID: WP_032899026.1
• Coordinates: 941848..942276 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0T9TYF0
• Locus tag: FFE93_RS04375
• Protein ID: WP_004706797.1
• Coordinates: 941601..941867 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFE93_RS04365	939631..940278	+	648	WP_138775204.1	hemolysin III family protein	-
FFE93_RS04370	940355..941347	-	993	WP_054872559.1	tRNA-modifying protein YgfZ	-
FFE93_RS04375	941601..941867	+	267	WP_004706797.1	FAD assembly factor SdhE	Antitoxin
FFE93_RS04380	941848..942276	+	429	WP_032899026.1	protein YgfX	Toxin
FFE93_RS04385	942273..942971	+	699	WP_032899028.1	two-component system response regulator CreB	-
FFE93_RS04390	943027..944454	+	1428	WP_138774847.1	two-component system sensor histidine kinase CreC	-
FFE93_RS04395	944547..945974	+	1428	WP_138774848.1	cell envelope integrity protein CreD	-
FFE93_RS04400	946033..946551	-	519	WP_032897254.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16586.52 Da
• Isoelectric Point: 9.3506

>T134933 WP_032899026.1 NZ_CP042173:941848-942276 [Yersinia sp. KBS0713]
VAQWRCDLRVSWHTQLFSLLTHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNLVLWKRL
EWMVVKQPWITRYGVLLSLKQASNHAIHKRLWLAADSMSEDEWRQLCLLLRHSFDADEGLNR

Nucleotide

• Length: 429 bp

>T134933 NZ_CP042173:941848-942276 [Yersinia sp. KBS0713]
GTGGCCCAGTGGCGATGTGACCTGCGGGTATCCTGGCACACTCAACTTTTCTCGTTATTGACGCACGGTGTTTTGGTGAT
ACTCACCTTGGTCGCGCCCTGGCCCCAGGGCTATACCGCACTATGGTTAGTATTGCTGACACTGGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAACATCACCTCCTGTCAGGGTGAAATCAGGCTTAAACCCGGCAATCTGGTGCTATGGAAAAGGCTC
GAATGGATGGTCGTTAAGCAGCCCTGGATCACCCGCTATGGGGTGTTGTTGAGCTTAAAACAGGCGAGTAACCACGCTAT
CCATAAGCGTTTATGGCTGGCGGCTGATAGCATGTCAGAAGATGAGTGGCGGCAACTCTGCCTGCTACTGCGCCACTCCT
TTGATGCTGATGAGGGTTTGAATCGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10487.02 Da
• Isoelectric Point: 4.8551

>AT134933 WP_004706797.1 NZ_CP042173:941601-941867 [Yersinia sp. KBS0713]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQARN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT134933 NZ_CP042173:941601-941867 [Yersinia sp. KBS0713]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGCCGTGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTCGAATATGAATATGATGGCTTGAGTGATAATGAGAAGCAGGTTTTTATTCGTTTACTTGAGTGCGATGACCCAGATT
TATTTAACTGGCTGATGAATCATGGGGAGCCGCAGGATAGTGAGCTGCGTCAGATGGTCAAATTGATTCAAGCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0T9TYF0