Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1774706..1775221 Replicon chromosome
Accession NZ_CP042169
Organism Micrococcus sp. KBS0714

Toxin (Protein)


Gene name relE Uniprot ID A0A229HFY8
Locus tag B1A86_RS08050 Protein ID WP_036340857.1
Coordinates 1774706..1774960 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag B1A86_RS08055 Protein ID WP_036340860.1
Coordinates 1774961..1775221 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1A86_RS08010 1769881..1770579 - 699 WP_036316501.1 aquaporin Z -
B1A86_RS08015 1770746..1771042 - 297 Protein_1547 hypothetical protein -
B1A86_RS08020 1771157..1771342 - 186 Protein_1548 hypothetical protein -
B1A86_RS08025 1771640..1772365 + 726 WP_186299915.1 MSMEG_4193 family putative phosphomutase -
B1A86_RS08030 1772362..1772904 + 543 WP_063190266.1 DUF3090 domain-containing protein -
B1A86_RS08035 1772904..1773686 + 783 WP_036340845.1 SCO1664 family protein -
B1A86_RS08040 1773700..1773945 - 246 WP_078025880.1 hypothetical protein -
B1A86_RS08045 1774138..1774704 - 567 WP_036340854.1 mismatch-specific DNA-glycosylase -
B1A86_RS08050 1774706..1774960 - 255 WP_036340857.1 Txe/YoeB family addiction module toxin Toxin
B1A86_RS08055 1774961..1775221 - 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B1A86_RS08060 1775407..1776810 + 1404 WP_036340863.1 GntP family permease -
B1A86_RS08065 1776840..1777994 + 1155 WP_052001283.1 glycerate kinase -
B1A86_RS08075 1778424..1778938 - 515 Protein_1558 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9970.25 Da        Isoelectric Point: 6.7245

>T134930 WP_036340857.1 NZ_CP042169:c1774960-1774706 [Micrococcus sp. KBS0714]
VRLVWDRSAWEDYTHWQTTDRKVLNRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T134930 NZ_CP042169:c1774960-1774706 [Micrococcus sp. KBS0714]
GTGCGCCTCGTGTGGGACCGCTCGGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTTCTCAACCGGAT
CAACACCCTCATTGACGCCGCCCTGCGTGATCCCTTCGAGGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCAGCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT134930 WP_036340860.1 NZ_CP042169:c1775221-1774961 [Micrococcus sp. KBS0714]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT134930 NZ_CP042169:c1775221-1774961 [Micrococcus sp. KBS0714]
ATGTCCATCAGCGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTGGA
GATCGTCTCCCGCAAGGGGAATGCCGTCCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCCGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTCGAGGAGCACGCTCTGGAC
CGCATGGACGGGGACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229HFY8

Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References