Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 141748..142342 Replicon plasmid unnamed1
Accession NZ_CP042167
Organism Burkholderia contaminans strain ZCC

Toxin (Protein)


Gene name PumA Uniprot ID A0A228JB64
Locus tag FPQ37_RS40960 Protein ID WP_027811055.1
Coordinates 142049..142342 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A228JAU5
Locus tag FPQ37_RS40955 Protein ID WP_027811056.1
Coordinates 141748..142047 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPQ37_RS40940 137051..139117 - 2067 WP_027811059.1 type IV secretion system DNA-binding domain-containing protein -
FPQ37_RS40945 139110..139511 - 402 WP_027811058.1 hypothetical protein -
FPQ37_RS40950 141274..141585 + 312 WP_027811057.1 hypothetical protein -
FPQ37_RS40955 141748..142047 - 300 WP_027811056.1 putative addiction module antidote protein Antitoxin
FPQ37_RS40960 142049..142342 - 294 WP_027811055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPQ37_RS42475 142447..142590 - 144 WP_154233621.1 hypothetical protein -
FPQ37_RS40965 142647..142868 - 222 WP_027811054.1 DUF3717 domain-containing protein -
FPQ37_RS40970 142913..143464 - 552 WP_077186813.1 hypothetical protein -
FPQ37_RS40975 143439..143705 - 267 WP_027811052.1 hypothetical protein -
FPQ37_RS40985 144746..146875 - 2130 WP_039350079.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..239952 239952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10854.50 Da        Isoelectric Point: 10.6086

>T134929 WP_027811055.1 NZ_CP042167:c142342-142049 [Burkholderia contaminans]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDMKPVGAGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

>T134929 NZ_CP042167:c142342-142049 [Burkholderia contaminans]
ATGAGAATCGAGCAGACAGACGACTTCGCGAAATGGTTGCGCGGCCTACGCGATCACATCGCGCGCGCGCAGATCGCCAA
GCGGATTCAACGGCTCGCGCGCGGCCAATATGGGGACATGAAGCCGGTGGGTGCCGGAGTGAGCGAAATGCGCGTGCACG
TCGGCCCCGGCTATCGCGTCTACTTTGTCCAACGAGGCTCAACGCTCGTCGTCCTGCTATGCGGTGGCGACAAGTCAACG
CAGCAGCGCGACATTGAGCGTGCTATCGCGCTTTCGGCGCAATTGGGAGATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10716.01 Da        Isoelectric Point: 4.6364

>AT134929 WP_027811056.1 NZ_CP042167:c142047-141748 [Burkholderia contaminans]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp

>AT134929 NZ_CP042167:c142047-141748 [Burkholderia contaminans]
ATGGGTATCAAGACAACGCCGTTCGATGCGGCCGAATACCTCGACACGCCCGAGGCGCAGGCCGAATATCTGCGGATTTC
GTTCGAGACCGGCGATTCCGCCGACATTCAGGAAGCCATCGGCACCGTGGCGCGTGCGCGTGGCATGACGCAGATTGCGC
GCGACGCGGGCGTCGGCCGCGAAAGCCTCTACAAAGCGCTGGACGAGCACGGCAACCCGGAATTCGCGACGATCCTGCGT
GTTGTGCGCGCGCTCGGCCTCACGTTGACCGTGACGACGCCCGTACACGAGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228JB64

Antitoxin

Source ID Structure
AlphaFold DB A0A228JAU5

References