Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 66811..67460 Replicon plasmid unnamed1
Accession NZ_CP042167
Organism Burkholderia contaminans strain ZCC

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPQ37_RS40590 Protein ID WP_027813527.1
Coordinates 66811..67221 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6P2T8K5
Locus tag FPQ37_RS40595 Protein ID WP_027813526.1
Coordinates 67218..67460 (-) Length 81 a.a.

Genomic Context

FPQ37_RS40605FPQ37_RS40610FPQ37_RS40615FPQ37_RS40555FPQ37_RS40560FPQ37_RS40565FPQ37_RS40570FPQ37_RS40575FPQ37_RS40580FPQ37_RS40585FPQ37_RS40590FPQ37_RS40595FPQ37_RS40600
Location: 69007..69678 (672 bp)
Type: Others
Protein ID: WP_027813524.1
Location: 69678..70643 (966 bp)
Type: Others
Protein ID: WP_027813523.1
Location: 71386..72243 (858 bp)
Type: Others
Protein ID: WP_027813522.1
Location: 62358..63206 (849 bp)
Type: Others
Protein ID: WP_027813534.1
Location: 63366..63596 (231 bp)
Type: Others
Protein ID: WP_027813533.1
Location: 63607..64692 (1086 bp)
Type: Others
Protein ID: WP_027813532.1
Location: 64737..65042 (306 bp)
Type: Others
Protein ID: WP_027813531.1
Location: 65063..65715 (653 bp)
Type: Others
Protein ID: Protein_66
Location: 65903..66103 (201 bp)
Type: Others
Protein ID: WP_034176085.1
Location: 66152..66499 (348 bp)
Type: Others
Protein ID: WP_027813528.1
Location: 66811..67221 (411 bp)
Type: Toxin
Protein ID: WP_027813527.1
Location: 67218..67460 (243 bp)
Type: Antitoxin
Protein ID: WP_027813526.1
Location: 67555..68604 (1050 bp)
Type: Others
Protein ID: WP_027813525.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPQ37_RS4055562358..63206-849WP_027813534.1heteromeric transposase endonuclease subunit TnsA-
FPQ37_RS4056063366..63596-231WP_027813533.1hypothetical protein-
FPQ37_RS4056563607..64692-1086WP_027813532.1hypothetical protein-
FPQ37_RS4057064737..65042-306WP_027813531.1hypothetical protein-
FPQ37_RS4057565063..65715-653Protein_66helix-turn-helix domain-containing protein-
FPQ37_RS4058065903..66103-201WP_034176085.1hypothetical protein-
FPQ37_RS4058566152..66499-348WP_027813528.1hypothetical protein-
FPQ37_RS4059066811..67221-411WP_027813527.1type II toxin-antitoxin system VapC family toxinToxin
FPQ37_RS4059567218..67460-243WP_027813526.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
FPQ37_RS4060067555..68604-1050WP_027813525.1non-homologous end-joining DNA ligase-
FPQ37_RS4060569007..69678+672WP_027813524.1AAA family ATPase-
FPQ37_RS4061069678..70643+966WP_027813523.1ParB/RepB/Spo0J family partition protein-
FPQ37_RS4061571386..72243+858WP_027813522.1replication initiator protein A-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..239952239952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(12-50)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14869.13 Da        Isoelectric Point: 4.8604

>T134928 WP_027813527.1 NZ_CP042167:c67221-66811 [Burkholderia contaminans]
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIDANDMLIAAHALAVDAVLVTDNTAEFTRIAGLPVENWLRPAT

Download         Length: 411 bp

>T134928 NZ_CP042167:c67221-66811 [Burkholderia contaminans]
ATGACGCTGTACCTGCTCGATACCAACATTTTGTCGAACGTGATCCGCGACCCGCGCGGCGCATGCGCCACCCGGATTGG
AGAAACGCCGCCCGAACAAGTGTGCACCTCGATCATCGTGGCCGCGGAATTGCGGTTCGGCGTCTGGAAGCGTGGCTCGT
CAACGCTCGCGCAGCGCGTCGAGCAGCTGCTCGCAAGCCTGACCGTGTTGCCGCTGCAACCGGACGCGGACCGCTGCTAC
GGGCGGTTGCGGGCCGAGCTCGAGAAGCAAGGCCAGTTGATCGACGCCAACGACATGCTGATCGCCGCGCATGCGCTGGC
CGTCGACGCCGTGCTGGTCACGGACAACACGGCTGAATTCACCCGTATCGCGGGGCTGCCGGTCGAAAACTGGCTGCGGC
CGGCGACGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9375.64 Da        Isoelectric Point: 4.6856

>AT134928 WP_027813526.1 NZ_CP042167:c67460-67218 [Burkholderia contaminans]
MPNHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDEIFPDIEDLPPEPVDIE

Download         Length: 243 bp

>AT134928 NZ_CP042167:c67460-67218 [Burkholderia contaminans]
ATGCCAAACCATGACACCCGCCACGCGCGCCTGTTCCGCAACGGGCGGAGCCAGGCCGTGCGGATCCCGCGCGAATTCGA
ACTGCCGGTGTCGGAGGTCACCATCCACCGGGAAGGTCGCCGCTTGATCATTGAGCCCGTAGAGGCCGCGCCCTTGCGCG
AGCTGTTCGCCCAATGGACCCCGCTGGACGAGATCTTCCCGGACATCGAGGACCTTCCGCCTGAACCGGTCGATATCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6P2T8K5

References