Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 190664..192414 Replicon chromosome
Accession NZ_CP042165
Organism Burkholderia contaminans strain ZCC

Toxin (Protein)


Gene name doc Uniprot ID A0A1E3FSX8
Locus tag FPQ37_RS19535 Protein ID WP_039344096.1
Coordinates 190664..191560 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1E3FSY5
Locus tag FPQ37_RS19540 Protein ID WP_039344097.1
Coordinates 191557..192414 (+) Length 286 a.a.

Genomic Context

FPQ37_RS19510FPQ37_RS19515FPQ37_RS19520FPQ37_RS19525FPQ37_RS19530FPQ37_RS19535FPQ37_RS19540FPQ37_RS19545FPQ37_RS19550FPQ37_RS19555FPQ37_RS19560FPQ37_RS19505
Location: 187558..187875 (318 bp)
Type: Others
Protein ID: WP_011354710.1
Location: 187877..188188 (312 bp)
Type: Others
Protein ID: WP_039344088.1
Location: 188241..189317 (1077 bp)
Type: Others
Protein ID: WP_039344090.1
Location: 189310..190080 (771 bp)
Type: Others
Protein ID: WP_039344092.1
Location: 190118..190645 (528 bp)
Type: Others
Protein ID: WP_039344094.1
Location: 190664..191560 (897 bp)
Type: Toxin
Protein ID: WP_039344096.1
Location: 191557..192414 (858 bp)
Type: Antitoxin
Protein ID: WP_039344097.1
Location: 192411..193208 (798 bp)
Type: Others
Protein ID: WP_039344099.1
Location: 193201..194868 (1668 bp)
Type: Others
Protein ID: WP_039344101.1
Location: 194861..195688 (828 bp)
Type: Others
Protein ID: WP_039344103.1
Location: 195761..197251 (1491 bp)
Type: Others
Protein ID: WP_039344105.1
Location: 186034..187113 (1080 bp)
Type: Others
Protein ID: WP_039344086.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPQ37_RS19505186034..187113-1080WP_039344086.1porin-
FPQ37_RS19510187558..187875+318WP_011354710.1non-heme iron oxygenase ferredoxin subunit-
FPQ37_RS19515187877..188188+312WP_039344088.1hypothetical protein-
FPQ37_RS19520188241..189317+1077WP_039344090.1aromatic ring-hydroxylating dioxygenase subunit alpha-
FPQ37_RS19525189310..190080+771WP_039344092.1SDR family oxidoreductase-
FPQ37_RS19530190118..190645+528WP_039344094.1cupin domain-containing protein-
FPQ37_RS19535190664..191560+897WP_039344096.1alpha/beta fold hydrolaseToxin
FPQ37_RS19540191557..192414+858WP_039344097.1IclR family transcriptional regulatorAntitoxin
FPQ37_RS19545192411..193208+798WP_039344099.1SDR family oxidoreductase-
FPQ37_RS19550193201..194868+1668WP_039344101.1thiamine pyrophosphate-binding protein-
FPQ37_RS19555194861..195688+828WP_039344103.1aspartate dehydrogenase-
FPQ37_RS19560195761..197251+1491WP_039344105.1aldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30700.99 Da        Isoelectric Point: 8.0624

>T134923 WP_039344096.1 NZ_CP042165:190664-191560 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

>T134923 NZ_CP042165:190664-191560 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCACCATGCGGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCAACTGCTCGCGAATGCCGATCTCGCAACGGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATTGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCACA
AGCGGGCCATGCCGGCTACGTGGAAGCACCGGCCGTCTATTCCGCACTGATCGACGCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31463.03 Da        Isoelectric Point: 6.7661

>AT134923 WP_039344097.1 NZ_CP042165:191557-192414 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT134923 NZ_CP042165:191557-192414 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACGACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGGACGCGCTTGCCCGCACATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGTTGAAGGAACTGCATGCGCTGTATCCGGAAGGCACGCTGAACCGCATGACGAACGCGAC
GCCGGAAACGGTCGATGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACACAGAGGATCGTGGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E3FSX8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E3FSY5

References