Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 190664..192414 Replicon chromosome
Accession NZ_CP042165
Organism Burkholderia contaminans strain ZCC

Toxin (Protein)


Gene name doc Uniprot ID A0A1E3FSX8
Locus tag FPQ37_RS19535 Protein ID WP_039344096.1
Coordinates 190664..191560 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1E3FSY5
Locus tag FPQ37_RS19540 Protein ID WP_039344097.1
Coordinates 191557..192414 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPQ37_RS19505 186034..187113 - 1080 WP_039344086.1 porin -
FPQ37_RS19510 187558..187875 + 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
FPQ37_RS19515 187877..188188 + 312 WP_039344088.1 hypothetical protein -
FPQ37_RS19520 188241..189317 + 1077 WP_039344090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
FPQ37_RS19525 189310..190080 + 771 WP_039344092.1 SDR family oxidoreductase -
FPQ37_RS19530 190118..190645 + 528 WP_039344094.1 cupin domain-containing protein -
FPQ37_RS19535 190664..191560 + 897 WP_039344096.1 alpha/beta fold hydrolase Toxin
FPQ37_RS19540 191557..192414 + 858 WP_039344097.1 IclR family transcriptional regulator Antitoxin
FPQ37_RS19545 192411..193208 + 798 WP_039344099.1 SDR family oxidoreductase -
FPQ37_RS19550 193201..194868 + 1668 WP_039344101.1 thiamine pyrophosphate-binding protein -
FPQ37_RS19555 194861..195688 + 828 WP_039344103.1 aspartate dehydrogenase -
FPQ37_RS19560 195761..197251 + 1491 WP_039344105.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30700.99 Da        Isoelectric Point: 8.0624

>T134923 WP_039344096.1 NZ_CP042165:190664-191560 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

>T134923 NZ_CP042165:190664-191560 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCACCATGCGGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCAACTGCTCGCGAATGCCGATCTCGCAACGGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATTGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCACA
AGCGGGCCATGCCGGCTACGTGGAAGCACCGGCCGTCTATTCCGCACTGATCGACGCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31463.03 Da        Isoelectric Point: 6.7661

>AT134923 WP_039344097.1 NZ_CP042165:191557-192414 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT134923 NZ_CP042165:191557-192414 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACGACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGGACGCGCTTGCCCGCACATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGTTGAAGGAACTGCATGCGCTGTATCCGGAAGGCACGCTGAACCGCATGACGAACGCGAC
GCCGGAAACGGTCGATGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACACAGAGGATCGTGGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FSX8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FSY5

References