Detailed information of TA system TA134922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3743931..3744604
• Replicon: chromosome
• Accession: NZ_CP042164
• Organism: Burkholderia contaminans strain ZCC

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2HB51
• Locus tag: FPQ37_RS17900
• Protein ID: WP_012431246.1
• Coordinates: 3744200..3744604 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2H4U0
• Locus tag: FPQ37_RS17895
• Protein ID: WP_012431247.1
• Coordinates: 3743931..3744203 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPQ37_RS17870	3740556..3740888	-	333	WP_012431252.1	VirB3 family type IV secretion system protein	-
FPQ37_RS17875	3740902..3741243	-	342	WP_039339345.1	TrbC/VirB2 family protein	-
FPQ37_RS17880	3741281..3741958	-	678	WP_012431250.1	lytic transglycosylase domain-containing protein	-
FPQ37_RS17885	3741955..3742518	-	564	WP_179945685.1	hypothetical protein	-
FPQ37_RS17890	3742532..3743404	-	873	WP_012431248.1	ParA family protein	-
FPQ37_RS17895	3743931..3744203	+	273	WP_012431247.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FPQ37_RS17900	3744200..3744604	+	405	WP_012431246.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPQ37_RS17905	3744895..3745221	-	327	WP_012431245.1	hypothetical protein	-
FPQ37_RS17910	3745218..3745460	-	243	WP_012431244.1	AlpA family transcriptional regulator	-
FPQ37_RS17915	3745712..3746746	-	1035	WP_012431243.1	porin	-
FPQ37_RS17920	3746828..3747373	-	546	WP_012431242.1	amino acid synthesis family protein	-
FPQ37_RS17925	3747370..3748797	-	1428	WP_012431241.1	amidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3687695..3769427	81732

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14466.86 Da
• Isoelectric Point: 6.4531

>T134922 WP_012431246.1 NZ_CP042164:3744200-3744604 [Burkholderia contaminans]
MNGYLLDTNVIRDMIRYPSGKVATHIGQIDPRAICTSVVVAAELRYGCARKGSEKLLARVESLLAIIPVLPLDVPADTEY
GGIRAELEIAGQPIGANELLIAAHACALGLTLVTDNTKVFSRIRGLAIENWLDR

Nucleotide

• Length: 405 bp

>T134922 NZ_CP042164:3744200-3744604 [Burkholderia contaminans]
TTGAACGGCTATCTGCTGGACACGAACGTCATCCGCGACATGATCCGCTATCCGTCCGGAAAGGTGGCCACCCATATCGG
GCAAATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCCAGAAAGGGTTCCG
AAAAATTGCTGGCCAGAGTGGAAAGCCTGCTTGCGATCATTCCCGTGCTGCCGCTGGACGTGCCTGCTGACACCGAATAC
GGGGGTATTCGTGCAGAGCTTGAGATTGCTGGCCAGCCGATCGGTGCAAACGAGCTTCTGATCGCGGCTCATGCCTGTGC
GTTGGGGCTCACACTCGTGACTGACAACACGAAGGTGTTCAGCCGCATACGCGGTCTTGCGATCGAGAACTGGCTTGACC
GGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10321.75 Da
• Isoelectric Point: 4.5112

>AT134922 WP_012431247.1 NZ_CP042164:3743931-3744203 [Burkholderia contaminans]
MPVPPPSGRPREARLFRNNRSQAVRIPVEFELPGDRVLIYREGDRLIIEPVKTPANIIELLDAWRQEPRFGPDDQFPDIE
DAPLQPEGIP

Nucleotide

• Length: 273 bp

>AT134922 NZ_CP042164:3743931-3744203 [Burkholderia contaminans]
ATGCCCGTGCCCCCTCCTTCCGGCCGCCCCAGGGAGGCCAGACTGTTCCGCAACAACCGGAGTCAGGCGGTACGCATCCC
GGTCGAATTCGAGTTGCCGGGTGATCGCGTCCTGATCTATCGGGAGGGCGACAGGCTCATCATCGAGCCGGTGAAAACCC
CCGCGAACATCATCGAATTGCTGGATGCATGGAGACAGGAGCCACGGTTCGGACCTGACGACCAGTTTCCGGATATTGAG
GATGCGCCTCTTCAGCCGGAGGGCATACCTTGA

Structures

Toxin

• AlphaFold DB: U2HB51

Antitoxin

• AlphaFold DB: U2H4U0