Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 175524..176161 Replicon chromosome
Accession NZ_CP042164
Organism Burkholderia contaminans strain ZCC

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag FPQ37_RS00765 Protein ID WP_039351354.1
Coordinates 175760..176161 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag FPQ37_RS00760 Protein ID WP_039351357.1
Coordinates 175524..175760 (+) Length 79 a.a.

Genomic Context

FPQ37_RS00740FPQ37_RS00760FPQ37_RS00765FPQ37_RS00745FPQ37_RS00750FPQ37_RS00770FPQ37_RS00775
Location: 171217..172248 (1032 bp)
Type: Others
Protein ID: WP_039351365.1
Location: 175524..175760 (237 bp)
Type: Antitoxin
Protein ID: WP_039351357.1
Location: 175760..176161 (402 bp)
Type: Toxin
Protein ID: WP_039351354.1
Location: 172366..173463 (1098 bp)
Type: Others
Protein ID: WP_039351363.1
Location: 173460..175163 (1704 bp)
Type: Others
Protein ID: WP_039351360.1
Location: 176232..177620 (1389 bp)
Type: Others
Protein ID: WP_039351351.1
Location: 177651..178787 (1137 bp)
Type: Others
Protein ID: WP_039351348.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPQ37_RS00740171217..172248+1032WP_039351365.1helix-turn-helix domain-containing protein-
FPQ37_RS00745172366..173463-1098WP_039351363.1ADP-heptose--LPS heptosyltransferase-
FPQ37_RS00750173460..175163-1704WP_039351360.1thiamine pyrophosphate-binding protein-
FPQ37_RS00760175524..175760+237WP_039351357.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
FPQ37_RS00765175760..176161+402WP_039351354.1type II toxin-antitoxin system VapC family toxinToxin
FPQ37_RS00770176232..177620-1389WP_039351351.1L-serine ammonia-lyase-
FPQ37_RS00775177651..178787-1137WP_039351348.1alginate lyase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T134920 WP_039351354.1 NZ_CP042164:175760-176161 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

>T134920 NZ_CP042164:175760-176161 [Burkholderia contaminans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGAATCAGCCGGAGCAGGTTGCGAGACGGTTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATCACGTACGCCGAGCTCGAGTACGGCGTCGCGGCGTGCGCGAGCC
CTGCGCGGGAGCGCGGCAATCTTGCCGCGCTGATCGACGACATTCCCGTTGCGCCGTTCGACGTCGCGGCCGCGCAAGCG
TATGGCCCGGTCCGCGAGGCAACCCGGGAGCGGAAGAAGGATCACCTCGACAAGCTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTACTCGTGACCAACAACGAGCGGGATTTCGTGAGCTATCCGGGACTGCGGCTGGAGAACTGGCTGGACGATT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT134920 WP_039351357.1 NZ_CP042164:175524-175760 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp

>AT134920 NZ_CP042164:175524-175760 [Burkholderia contaminans]
ATGCATACGACGAGGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTTGCCTATGAACGCAGCGA
TATCGAACTGGAAATCGAGCGCATTGGTGACGAAATCCGCATTCGGCCGGCGCGGCGGCCGTTGACCCGCGTCCTTGAGA
AATTCGCTAAATTCGGGCCGGATTTCATGGCGGATGGGCGCGGTGACCACGAGCAGGCCGATCGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A228K4S8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E3FXY0

References