Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1660177..1660654 Replicon chromosome
Accession NZ_CP042157
Organism Staphylococcus aureus strain B3-17D

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FP481_RS08420 Protein ID WP_000052076.1
Coordinates 1660177..1660365 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FP481_RS08425 Protein ID WP_001059690.1
Coordinates 1660394..1660654 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP481_RS08390 1656171..1656692 + 522 WP_000824481.1 hypothetical protein -
FP481_RS08395 1657033..1657719 + 687 WP_000141557.1 thermonuclease family protein -
FP481_RS08400 1658076..1658276 + 201 WP_001059082.1 cold-shock protein -
FP481_RS08405 1658768..1658986 - 219 WP_000005886.1 hypothetical protein -
FP481_RS08410 1659048..1659332 - 285 WP_001004399.1 hypothetical protein -
FP481_RS08415 1659420..1659989 - 570 WP_001106654.1 hypothetical protein -
FP481_RS08420 1660177..1660365 - 189 WP_000052076.1 hypothetical protein Toxin
FP481_RS08425 1660394..1660654 - 261 WP_001059690.1 hypothetical protein Antitoxin
FP481_RS08430 1660995..1661198 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FP481_RS08435 1661195..1661431 - 237 WP_000349581.1 hypothetical protein -
FP481_RS08440 1661656..1662237 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FP481_RS08445 1662310..1662927 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FP481_RS08450 1663082..1663576 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FP481_RS08455 1663975..1664397 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FP481_RS08460 1664545..1665261 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T134914 WP_000052076.1 NZ_CP042157:c1660365-1660177 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T134914 NZ_CP042157:c1660365-1660177 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT134914 WP_001059690.1 NZ_CP042157:c1660654-1660394 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT134914 NZ_CP042157:c1660654-1660394 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References