Detailed information of TA system TA134905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 70476..71273
• Replicon: chromosome
• Accession: NZ_CP042157
• Organism: Staphylococcus aureus strain B3-17D

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FP481_RS00475
• Protein ID: WP_000525014.1
• Coordinates: 70812..71273 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: FP481_RS00470
• Protein ID: WP_001260487.1
• Coordinates: 70476..70799 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP481_RS00400	65535..66293	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
FP481_RS00405	66304..66627	-	324	WP_000171560.1	hypothetical protein	-
FP481_RS00410	66640..67251	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
FP481_RS00415	67274..67510	-	237	WP_000802314.1	hypothetical protein	-
FP481_RS00420	67518..67778	-	261	WP_000291082.1	DUF1108 family protein	-
FP481_RS00425	67877..68038	-	162	WP_001285953.1	DUF1270 family protein	-
FP481_RS00430	68035..68355	-	321	WP_001120202.1	DUF771 domain-containing protein	-
FP481_RS00440	68506..68649	-	144	WP_000939498.1	hypothetical protein	-
FP481_RS00445	68716..68938	+	223	Protein_87	hypothetical protein	-
FP481_RS00455	69191..69403	+	213	WP_000362645.1	hypothetical protein	-
FP481_RS14605	69444..69593	-	150	WP_000771849.1	hypothetical protein	-
FP481_RS00460	69608..70051	-	444	WP_000435352.1	hypothetical protein	-
FP481_RS00465	70064..70312	-	249	WP_000272856.1	helix-turn-helix domain-containing protein	-
FP481_RS00470	70476..70799	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
FP481_RS00475	70812..71273	+	462	WP_000525014.1	hypothetical protein	Toxin
FP481_RS00480	71290..71511	+	222	Protein_94	membrane lipoprotein lipid attachment site-containing protein	-
FP481_RS00485	71805..72689	+	885	WP_001025527.1	hypothetical protein	-
FP481_RS00490	72995..73363	+	369	Protein_96	hypothetical protein	-
FP481_RS14610	73462..73629	+	168	WP_001166555.1	hypothetical protein	-
FP481_RS00495	73969..74673	+	705	Protein_98	type II toxin-antitoxin system PemK/MazF family toxin	-
FP481_RS00500	74835..75872	+	1038	WP_000857172.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	32683..84952	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T134905 WP_000525014.1 NZ_CP042157:70812-71273 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T134905 NZ_CP042157:70812-71273 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT134905 WP_001260487.1 NZ_CP042157:70476-70799 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT134905 NZ_CP042157:70476-70799 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36