Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2194178..2194692 Replicon chromosome
Accession NZ_CP042153
Organism Staphylococcus aureus strain B4-59C

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FP482_RS10970 Protein ID WP_000581792.1
Coordinates 2194178..2194387 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FP482_RS10975 Protein ID WP_000138932.1
Coordinates 2194399..2194692 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP482_RS10950 2189686..2191044 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FP482_RS10955 2191059..2192129 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FP482_RS10960 2192447..2193649 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FP482_RS10965 2193913..2194050 - 138 WP_000828354.1 hypothetical protein -
FP482_RS10970 2194178..2194387 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FP482_RS10975 2194399..2194692 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FP482_RS10980 2194858..2196342 + 1485 WP_145411590.1 cardiolipin synthase -
FP482_RS10985 2196370..2197017 + 648 WP_001187630.1 HD domain-containing protein -
FP482_RS11005 2197741..2198613 - 873 WP_000725802.1 membrane protein insertase YidC -
FP482_RS11010 2198699..2199340 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T134895 WP_000581792.1 NZ_CP042153:c2194387-2194178 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T134895 NZ_CP042153:c2194387-2194178 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT134895 WP_000138932.1 NZ_CP042153:c2194692-2194399 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT134895 NZ_CP042153:c2194692-2194399 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References