Detailed information of TA system TA134893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2110057..2110854
• Replicon: chromosome
• Accession: NZ_CP042153
• Organism: Staphylococcus aureus strain B4-59C

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FP482_RS10575
• Protein ID: WP_000525014.1
• Coordinates: 2110393..2110854 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: FP482_RS10570
• Protein ID: WP_001260487.1
• Coordinates: 2110057..2110380 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP482_RS10500	2105116..2105874	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
FP482_RS10505	2105885..2106208	-	324	WP_000171560.1	hypothetical protein	-
FP482_RS10510	2106221..2106832	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
FP482_RS10515	2106855..2107091	-	237	WP_000802314.1	hypothetical protein	-
FP482_RS10520	2107099..2107359	-	261	WP_000291082.1	DUF1108 family protein	-
FP482_RS10525	2107458..2107619	-	162	WP_001285953.1	DUF1270 family protein	-
FP482_RS10530	2107616..2107936	-	321	WP_001120202.1	DUF771 domain-containing protein	-
FP482_RS10540	2108087..2108230	-	144	WP_000939498.1	hypothetical protein	-
FP482_RS10545	2108297..2108519	+	223	Protein_1999	hypothetical protein	-
FP482_RS10555	2108772..2108984	+	213	WP_000362645.1	hypothetical protein	-
FP482_RS14220	2109025..2109174	-	150	WP_000771849.1	hypothetical protein	-
FP482_RS10560	2109189..2109632	-	444	WP_000435352.1	hypothetical protein	-
FP482_RS10565	2109645..2109893	-	249	WP_000272856.1	helix-turn-helix domain-containing protein	-
FP482_RS10570	2110057..2110380	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
FP482_RS10575	2110393..2110854	+	462	WP_000525014.1	hypothetical protein	Toxin
FP482_RS10580	2110871..2111092	+	222	Protein_2006	membrane lipoprotein lipid attachment site-containing protein	-
FP482_RS10585	2111386..2112270	+	885	WP_001025527.1	hypothetical protein	-
FP482_RS10590	2112576..2112944	+	369	Protein_2008	hypothetical protein	-
FP482_RS14225	2113043..2113210	+	168	WP_001166555.1	hypothetical protein	-
FP482_RS10595	2113550..2114254	+	705	Protein_2010	type II toxin-antitoxin system PemK/MazF family toxin	-
FP482_RS10600	2114416..2115453	+	1038	WP_000857172.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2072264..2124533	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T134893 WP_000525014.1 NZ_CP042153:2110393-2110854 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T134893 NZ_CP042153:2110393-2110854 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT134893 WP_001260487.1 NZ_CP042153:2110057-2110380 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT134893 NZ_CP042153:2110057-2110380 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36