Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 902047..902524 Replicon chromosome
Accession NZ_CP042153
Organism Staphylococcus aureus strain B4-59C

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FP482_RS04355 Protein ID WP_000052076.1
Coordinates 902047..902235 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FP482_RS04360 Protein ID WP_001059690.1
Coordinates 902264..902524 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP482_RS04325 898041..898562 + 522 WP_000824481.1 hypothetical protein -
FP482_RS04330 898903..899589 + 687 WP_000141557.1 thermonuclease family protein -
FP482_RS04335 899946..900146 + 201 WP_001059082.1 cold-shock protein -
FP482_RS04340 900638..900856 - 219 WP_000005886.1 hypothetical protein -
FP482_RS04345 900918..901202 - 285 WP_001004399.1 hypothetical protein -
FP482_RS04350 901290..901859 - 570 WP_001106654.1 hypothetical protein -
FP482_RS04355 902047..902235 - 189 WP_000052076.1 hypothetical protein Toxin
FP482_RS04360 902264..902524 - 261 WP_001059690.1 hypothetical protein Antitoxin
FP482_RS04365 902865..903068 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FP482_RS04370 903065..903301 - 237 WP_000349581.1 hypothetical protein -
FP482_RS04375 903526..904107 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FP482_RS04380 904180..904797 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FP482_RS04385 904952..905446 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FP482_RS04395 905845..906267 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FP482_RS04400 906415..907131 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 888183..926672 38489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T134887 WP_000052076.1 NZ_CP042153:c902235-902047 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T134887 NZ_CP042153:c902235-902047 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT134887 WP_001059690.1 NZ_CP042153:c902524-902264 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT134887 NZ_CP042153:c902524-902264 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References