Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2722111..2722625 Replicon chromosome
Accession NZ_CP042107
Organism Staphylococcus aureus strain B8-13D

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FP484_RS13810 Protein ID WP_000581792.1
Coordinates 2722111..2722320 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FP484_RS13815 Protein ID WP_000138932.1
Coordinates 2722332..2722625 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP484_RS13790 2717619..2718977 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FP484_RS13795 2718992..2720062 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FP484_RS13800 2720380..2721582 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FP484_RS13805 2721846..2721983 - 138 WP_000828354.1 hypothetical protein -
FP484_RS13810 2722111..2722320 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FP484_RS13815 2722332..2722625 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FP484_RS13820 2722791..2724275 + 1485 WP_000571553.1 cardiolipin synthase -
FP484_RS13825 2724303..2724950 + 648 WP_001187630.1 HD domain-containing protein -
FP484_RS13850 2725863..2726735 - 873 WP_000725802.1 membrane protein insertase YidC -
FP484_RS13855 2726821..2727462 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T134883 WP_000581792.1 NZ_CP042107:c2722320-2722111 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T134883 NZ_CP042107:c2722320-2722111 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT134883 WP_000138932.1 NZ_CP042107:c2722625-2722332 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT134883 NZ_CP042107:c2722625-2722332 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References