Detailed information of TA system TA134882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2702372..2702901
• Replicon: chromosome
• Accession: NZ_CP042107
• Organism: Staphylococcus aureus strain B8-13D

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FP484_RS13720
• Protein ID: WP_000621175.1
• Coordinates: 2702372..2702734 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: FP484_RS13725
• Protein ID: WP_000948331.1
• Coordinates: 2702731..2702901 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP484_RS13695	2697908..2699227	+	1320	WP_001557163.1	ISL3-like element IS1181 family transposase	-
FP484_RS13700	2699350..2700120	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
FP484_RS13705	2700095..2700574	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
FP484_RS13710	2700576..2700902	-	327	WP_001052491.1	anti-sigma factor antagonist	-
FP484_RS13715	2701021..2702022	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
FP484_RS13720	2702372..2702734	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FP484_RS13725	2702731..2702901	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
FP484_RS13730	2702986..2704134	-	1149	WP_001281154.1	alanine racemase	-
FP484_RS13735	2704200..2704559	-	360	WP_000581197.1	holo-ACP synthase	-
FP484_RS13740	2704563..2705054	-	492	WP_001205912.1	PH domain-containing protein	-
FP484_RS13745	2705041..2706624	-	1584	WP_001294626.1	PH domain-containing protein	-
FP484_RS13750	2706617..2707096	-	480	WP_001287087.1	hypothetical protein	-
FP484_RS13755	2707304..2707864	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2697908..2699227	1319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T134882 WP_000621175.1 NZ_CP042107:c2702734-2702372 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T134882 NZ_CP042107:c2702734-2702372 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT134882 WP_000948331.1 NZ_CP042107:c2702901-2702731 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT134882 NZ_CP042107:c2702901-2702731 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1