Detailed information of TA system TA134881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2639466..2640263
• Replicon: chromosome
• Accession: NZ_CP042107
• Organism: Staphylococcus aureus strain B8-13D

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FP484_RS13420
• Protein ID: WP_000525014.1
• Coordinates: 2639802..2640263 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: FP484_RS13415
• Protein ID: WP_001260487.1
• Coordinates: 2639466..2639789 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP484_RS13345	2634525..2635283	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
FP484_RS13350	2635294..2635617	-	324	WP_000171560.1	hypothetical protein	-
FP484_RS13355	2635630..2636241	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
FP484_RS13360	2636264..2636500	-	237	WP_000802314.1	hypothetical protein	-
FP484_RS13365	2636508..2636768	-	261	WP_000291082.1	DUF1108 family protein	-
FP484_RS13370	2636867..2637028	-	162	WP_001285953.1	DUF1270 family protein	-
FP484_RS13375	2637025..2637345	-	321	WP_001120202.1	DUF771 domain-containing protein	-
FP484_RS13385	2637496..2637639	-	144	WP_000939498.1	hypothetical protein	-
FP484_RS13390	2637706..2637928	+	223	Protein_2557	hypothetical protein	-
FP484_RS13400	2638181..2638393	+	213	WP_000362645.1	hypothetical protein	-
FP484_RS14450	2638434..2638583	-	150	WP_000771849.1	hypothetical protein	-
FP484_RS13405	2638598..2639041	-	444	WP_000435352.1	hypothetical protein	-
FP484_RS13410	2639054..2639302	-	249	WP_000272856.1	helix-turn-helix domain-containing protein	-
FP484_RS13415	2639466..2639789	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
FP484_RS13420	2639802..2640263	+	462	WP_000525014.1	hypothetical protein	Toxin
FP484_RS13425	2640280..2640501	+	222	Protein_2564	membrane lipoprotein lipid attachment site-containing protein	-
FP484_RS13430	2640795..2641679	+	885	WP_001025527.1	hypothetical protein	-
FP484_RS13435	2641985..2642353	+	369	Protein_2566	hypothetical protein	-
FP484_RS14455	2642452..2642619	+	168	WP_001166555.1	hypothetical protein	-
FP484_RS13440	2642959..2643663	+	705	Protein_2568	type II toxin-antitoxin system PemK/MazF family toxin	-
FP484_RS13445	2643825..2644862	+	1038	WP_000857172.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2601673..2656967	55294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T134881 WP_000525014.1 NZ_CP042107:2639802-2640263 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T134881 NZ_CP042107:2639802-2640263 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT134881 WP_001260487.1 NZ_CP042107:2639466-2639789 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT134881 NZ_CP042107:2639466-2639789 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36