Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1389524..1390001 Replicon chromosome
Accession NZ_CP042107
Organism Staphylococcus aureus strain B8-13D

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FP484_RS06890 Protein ID WP_000052076.1
Coordinates 1389524..1389712 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FP484_RS06895 Protein ID WP_001059690.1
Coordinates 1389741..1390001 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP484_RS06860 1385518..1386039 + 522 WP_000824481.1 hypothetical protein -
FP484_RS06865 1386380..1387066 + 687 WP_000141557.1 thermonuclease family protein -
FP484_RS06870 1387423..1387623 + 201 WP_001059082.1 cold-shock protein -
FP484_RS06875 1388115..1388333 - 219 WP_000005886.1 hypothetical protein -
FP484_RS06880 1388395..1388679 - 285 WP_001004399.1 hypothetical protein -
FP484_RS06885 1388767..1389336 - 570 WP_001106654.1 hypothetical protein -
FP484_RS06890 1389524..1389712 - 189 WP_000052076.1 hypothetical protein Toxin
FP484_RS06895 1389741..1390001 - 261 WP_001059690.1 hypothetical protein Antitoxin
FP484_RS06900 1390342..1390545 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FP484_RS06905 1390542..1390778 - 237 WP_000349581.1 hypothetical protein -
FP484_RS06910 1391003..1391584 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FP484_RS06915 1391657..1392274 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FP484_RS06920 1392429..1392923 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FP484_RS06925 1393322..1393744 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FP484_RS06930 1393892..1394608 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T134875 WP_000052076.1 NZ_CP042107:c1389712-1389524 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T134875 NZ_CP042107:c1389712-1389524 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT134875 WP_001059690.1 NZ_CP042107:c1390001-1389741 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT134875 NZ_CP042107:c1390001-1389741 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References