Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1735037..1735514 Replicon chromosome
Accession NZ_CP042046
Organism Staphylococcus aureus strain B2-7A

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FP477_RS08825 Protein ID WP_000052076.1
Coordinates 1735037..1735225 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FP477_RS08830 Protein ID WP_001059690.1
Coordinates 1735254..1735514 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP477_RS08795 1731040..1731549 + 510 WP_000824480.1 hypothetical protein -
FP477_RS08800 1731890..1732576 + 687 WP_145377312.1 thermonuclease family protein -
FP477_RS08805 1732933..1733133 + 201 WP_001059082.1 cold-shock protein -
FP477_RS08810 1733628..1733846 - 219 WP_000005889.1 hypothetical protein -
FP477_RS08815 1733908..1734192 - 285 WP_001004395.1 hypothetical protein -
FP477_RS08820 1734280..1734849 - 570 WP_001106654.1 hypothetical protein -
FP477_RS08825 1735037..1735225 - 189 WP_000052076.1 hypothetical protein Toxin
FP477_RS08830 1735254..1735514 - 261 WP_001059690.1 hypothetical protein Antitoxin
FP477_RS08835 1735854..1736057 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FP477_RS08840 1736054..1736290 - 237 WP_000368687.1 hypothetical protein -
FP477_RS08845 1736515..1737096 + 582 WP_001140690.1 phosphoglycerate mutase family protein -
FP477_RS08850 1737169..1737786 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FP477_RS08855 1737940..1738434 - 495 WP_145389812.1 GNAT family N-acetyltransferase -
FP477_RS08860 1738833..1739255 - 423 WP_000974447.1 organic hydroperoxide resistance protein -
FP477_RS08865 1739403..1740119 + 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T134870 WP_000052076.1 NZ_CP042046:c1735225-1735037 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T134870 NZ_CP042046:c1735225-1735037 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT134870 WP_001059690.1 NZ_CP042046:c1735514-1735254 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT134870 NZ_CP042046:c1735514-1735254 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References