Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 258839..259353 Replicon chromosome
Accession NZ_CP042046
Organism Staphylococcus aureus strain B2-7A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag FP477_RS01535 Protein ID WP_000581793.1
Coordinates 258839..259048 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FP477_RS01540 Protein ID WP_000138932.1
Coordinates 259060..259353 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP477_RS01515 254348..255706 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FP477_RS01520 255721..256791 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FP477_RS01525 257109..258311 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FP477_RS01530 258574..258711 - 138 WP_000828354.1 hypothetical protein -
FP477_RS01535 258839..259048 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
FP477_RS01540 259060..259353 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FP477_RS01545 259519..261003 + 1485 WP_000571552.1 cardiolipin synthase -
FP477_RS01550 261031..261678 + 648 WP_001187627.1 HD domain-containing protein -
FP477_RS01570 262390..263262 - 873 WP_000725802.1 membrane protein insertase YidC -
FP477_RS01575 263348..263989 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T134864 WP_000581793.1 NZ_CP042046:c259048-258839 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T134864 NZ_CP042046:c259048-258839 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT134864 WP_000138932.1 NZ_CP042046:c259353-259060 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT134864 NZ_CP042046:c259353-259060 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References