Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2387833..2388347 Replicon chromosome
Accession NZ_CP042043
Organism Staphylococcus aureus strain B2-15A

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FP478_RS12020 Protein ID WP_000581792.1
Coordinates 2387833..2388042 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FP478_RS12025 Protein ID WP_000138932.1
Coordinates 2388054..2388347 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP478_RS12000 2383341..2384699 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FP478_RS12005 2384714..2385784 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FP478_RS12010 2386102..2387304 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FP478_RS12015 2387568..2387705 - 138 WP_000828354.1 hypothetical protein -
FP478_RS12020 2387833..2388042 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FP478_RS12025 2388054..2388347 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FP478_RS12030 2388513..2389997 + 1485 WP_000571553.1 cardiolipin synthase -
FP478_RS12035 2390025..2390672 + 648 WP_001187630.1 HD domain-containing protein -
FP478_RS12060 2391585..2392457 - 873 WP_000725802.1 membrane protein insertase YidC -
FP478_RS12065 2392543..2393184 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T134854 WP_000581792.1 NZ_CP042043:c2388042-2387833 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T134854 NZ_CP042043:c2388042-2387833 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT134854 WP_000138932.1 NZ_CP042043:c2388347-2388054 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT134854 NZ_CP042043:c2388347-2388054 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References