Detailed information of TA system TA134852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2305254..2306051
• Replicon: chromosome
• Accession: NZ_CP042043
• Organism: Staphylococcus aureus strain B2-15A

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FP478_RS11630
• Protein ID: WP_000525014.1
• Coordinates: 2305590..2306051 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: FP478_RS11625
• Protein ID: WP_001260487.1
• Coordinates: 2305254..2305577 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP478_RS11555	2300313..2301071	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
FP478_RS11560	2301082..2301405	-	324	WP_000171560.1	hypothetical protein	-
FP478_RS11565	2301418..2302029	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
FP478_RS11570	2302052..2302288	-	237	WP_000802314.1	hypothetical protein	-
FP478_RS11575	2302296..2302556	-	261	WP_000291082.1	DUF1108 family protein	-
FP478_RS11580	2302655..2302816	-	162	WP_001285953.1	DUF1270 family protein	-
FP478_RS11585	2302813..2303133	-	321	WP_001120202.1	DUF771 domain-containing protein	-
FP478_RS11595	2303284..2303427	-	144	WP_000939498.1	hypothetical protein	-
FP478_RS11600	2303494..2303716	+	223	Protein_2206	hypothetical protein	-
FP478_RS11610	2303969..2304181	+	213	WP_000362645.1	hypothetical protein	-
FP478_RS14415	2304222..2304371	-	150	WP_000771849.1	hypothetical protein	-
FP478_RS11615	2304386..2304829	-	444	WP_000435352.1	hypothetical protein	-
FP478_RS11620	2304842..2305090	-	249	WP_000272856.1	helix-turn-helix domain-containing protein	-
FP478_RS11625	2305254..2305577	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
FP478_RS11630	2305590..2306051	+	462	WP_000525014.1	hypothetical protein	Toxin
FP478_RS11635	2306068..2306289	+	222	Protein_2213	membrane lipoprotein lipid attachment site-containing protein	-
FP478_RS11640	2306583..2307467	+	885	WP_001025527.1	hypothetical protein	-
FP478_RS11645	2307773..2308141	+	369	Protein_2215	hypothetical protein	-
FP478_RS14420	2308240..2308407	+	168	WP_001166555.1	hypothetical protein	-
FP478_RS11650	2308747..2309451	+	705	Protein_2217	type II toxin-antitoxin system PemK/MazF family toxin	-
FP478_RS11655	2309613..2310650	+	1038	WP_000857172.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2266376..2319730	53354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T134852 WP_000525014.1 NZ_CP042043:2305590-2306051 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T134852 NZ_CP042043:2305590-2306051 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT134852 WP_001260487.1 NZ_CP042043:2305254-2305577 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT134852 NZ_CP042043:2305254-2305577 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36