Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1056593..1057070 Replicon chromosome
Accession NZ_CP042043
Organism Staphylococcus aureus strain B2-15A

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FP478_RS05115 Protein ID WP_000052076.1
Coordinates 1056593..1056781 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FP478_RS05120 Protein ID WP_001059690.1
Coordinates 1056810..1057070 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP478_RS05085 1052587..1053108 + 522 WP_000824481.1 hypothetical protein -
FP478_RS05090 1053449..1054135 + 687 WP_000141557.1 thermonuclease family protein -
FP478_RS05095 1054492..1054692 + 201 WP_001059082.1 cold-shock protein -
FP478_RS05100 1055184..1055402 - 219 WP_000005886.1 hypothetical protein -
FP478_RS05105 1055464..1055748 - 285 WP_001004399.1 hypothetical protein -
FP478_RS05110 1055836..1056405 - 570 WP_001106654.1 hypothetical protein -
FP478_RS05115 1056593..1056781 - 189 WP_000052076.1 hypothetical protein Toxin
FP478_RS05120 1056810..1057070 - 261 WP_001059690.1 hypothetical protein Antitoxin
FP478_RS05125 1057411..1057614 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FP478_RS05130 1057611..1057847 - 237 WP_000349581.1 hypothetical protein -
FP478_RS05135 1058072..1058653 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FP478_RS05140 1058726..1059343 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FP478_RS05145 1059498..1059992 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FP478_RS05150 1060391..1060813 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FP478_RS05155 1060961..1061677 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T134846 WP_000052076.1 NZ_CP042043:c1056781-1056593 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T134846 NZ_CP042043:c1056781-1056593 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT134846 WP_001059690.1 NZ_CP042043:c1057070-1056810 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT134846 NZ_CP042043:c1057070-1056810 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References