Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2542532..2543320 Replicon chromosome
Accession NZ_CP042003
Organism Staphylococcus aureus strain B3-14B

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag FP480_RS12870 Protein ID WP_000525009.1
Coordinates 2542859..2543320 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag FP480_RS12865 Protein ID WP_000333630.1
Coordinates 2542532..2542846 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP480_RS12800 2537560..2537820 - 261 WP_001556704.1 DUF1108 family protein -
FP480_RS12805 2537825..2538142 - 318 WP_000829613.1 hypothetical protein -
FP480_RS12810 2538231..2538392 - 162 WP_000048124.1 DUF1270 family protein -
FP480_RS12815 2538406..2538615 - 210 WP_000455727.1 hypothetical protein -
FP480_RS12820 2538628..2539341 - 714 WP_031925041.1 ORF6C domain-containing protein -
FP480_RS12825 2539398..2539607 + 210 WP_000772137.1 hypothetical protein -
FP480_RS12830 2539600..2539740 - 141 WP_000939495.1 hypothetical protein -
FP480_RS12835 2539771..2539968 - 198 WP_001148861.1 hypothetical protein -
FP480_RS12840 2539984..2540736 - 753 WP_001148642.1 phage antirepressor KilAC domain-containing protein -
FP480_RS12845 2540738..2540923 - 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
FP480_RS12850 2541368..2541850 + 483 WP_000394410.1 hypothetical protein -
FP480_RS12855 2541951..2542130 - 180 WP_000438352.1 hypothetical protein -
FP480_RS12860 2542144..2542380 - 237 WP_001121116.1 helix-turn-helix domain-containing protein -
FP480_RS12865 2542532..2542846 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
FP480_RS12870 2542859..2543320 + 462 WP_000525009.1 hypothetical protein Toxin
FP480_RS12875 2543339..2543842 + 504 WP_033857437.1 hypothetical protein -
FP480_RS12880 2543904..2544953 + 1050 WP_000146088.1 site-specific integrase -
FP480_RS12890 2545375..2546838 - 1464 WP_000503590.1 glutamate synthase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2494895..2544953 50058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T134841 WP_000525009.1 NZ_CP042003:2542859-2543320 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T134841 NZ_CP042003:2542859-2543320 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGTTTTATCTCAGCTGTTCCGTTACGTGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATACAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCATTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT134841 WP_000333630.1 NZ_CP042003:2542532-2542846 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT134841 NZ_CP042003:2542532-2542846 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References