Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2137083..2137559 Replicon chromosome
Accession NZ_CP042003
Organism Staphylococcus aureus strain B3-14B

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FP480_RS10715 Protein ID WP_000052076.1
Coordinates 2137371..2137559 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FP480_RS10710 Protein ID WP_001059690.1
Coordinates 2137083..2137343 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP480_RS10675 2132481..2133197 - 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -
FP480_RS10680 2133345..2133767 + 423 WP_000974452.1 organic hydroperoxide resistance protein -
FP480_RS10685 2134166..2134660 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
FP480_RS10690 2134809..2135426 + 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
FP480_RS10695 2135499..2136080 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
FP480_RS10700 2136305..2136541 + 237 WP_000368687.1 hypothetical protein -
FP480_RS10705 2136538..2136741 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FP480_RS10710 2137083..2137343 + 261 WP_001059690.1 hypothetical protein Antitoxin
FP480_RS10715 2137371..2137559 + 189 WP_000052076.1 hypothetical protein Toxin
FP480_RS10720 2137747..2138316 + 570 WP_001106655.1 hypothetical protein -
FP480_RS10725 2138404..2138688 + 285 WP_001004403.1 hypothetical protein -
FP480_RS10730 2138749..2138967 + 219 WP_000005881.1 hypothetical protein -
FP480_RS10735 2139464..2139664 - 201 WP_001059082.1 cold-shock protein -
FP480_RS10740 2140021..2140707 - 687 WP_001574556.1 thermonuclease family protein -
FP480_RS10745 2141048..2141530 - 483 WP_000824489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T134839 WP_000052076.1 NZ_CP042003:2137371-2137559 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T134839 NZ_CP042003:2137371-2137559 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT134839 WP_001059690.1 NZ_CP042003:2137083-2137343 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT134839 NZ_CP042003:2137083-2137343 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References