Detailed information of TA system TA134827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2020079..2020703
• Replicon: chromosome
• Accession: NZ_CP042002
• Organism: Streptococcus agalactiae strain GBS30

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: FP512_RS10155
• Protein ID: WP_000253103.1
• Coordinates: 2020079..2020426 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: FP512_RS10160
• Protein ID: WP_000543070.1
• Coordinates: 2020416..2020703 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP512_RS10135	2015794..2016150	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
FP512_RS10140	2016217..2018535	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
FP512_RS10145	2018674..2019213	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
FP512_RS10150	2019299..2019595	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
FP512_RS10155	2020079..2020426	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FP512_RS10160	2020416..2020703	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FP512_RS10165	2020772..2021149	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
FP512_RS10170	2021124..2021276	-	153	Protein_1932	DUF1492 domain-containing protein	-
FP512_RS10175	2021283..2021771	-	489	WP_000891151.1	hypothetical protein	-
FP512_RS10180	2021844..2022401	-	558	WP_001258765.1	hypothetical protein	-
FP512_RS10185	2022559..2022732	-	174	WP_000694573.1	hypothetical protein	-
FP512_RS10190	2022729..2022986	-	258	WP_001069293.1	hypothetical protein	-
FP512_RS10195	2023279..2024673	-	1395	WP_000656430.1	hypothetical protein	-
FP512_RS10200	2024685..2025542	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2009020..2036580	27560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T134827 WP_000253103.1 NZ_CP042002:c2020426-2020079 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T134827 NZ_CP042002:c2020426-2020079 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT134827 WP_000543070.1 NZ_CP042002:c2020703-2020416 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT134827 NZ_CP042002:c2020703-2020416 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5