Detailed information of TA system TA134824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 238906..239518
• Replicon: chromosome
• Accession: NZ_CP042001
• Organism: Streptococcus agalactiae strain GBS28

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: FP511_RS01405
• Protein ID: WP_000384859.1
• Coordinates: 238906..239241 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: FP511_RS01410
• Protein ID: WP_000259017.1
• Coordinates: 239231..239518 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP511_RS01380	234104..234745	+	642	WP_000591144.1	hypothetical protein	-
FP511_RS01385	235045..235920	+	876	WP_000421240.1	hypothetical protein	-
FP511_RS01390	235956..236390	+	435	WP_001220479.1	hypothetical protein	-
FP511_RS01395	236707..237963	+	1257	WP_000122836.1	plasmid recombination protein	-
FP511_RS01400	238131..238601	+	471	WP_000130119.1	hypothetical protein	-
FP511_RS01405	238906..239241	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FP511_RS01410	239231..239518	-	288	WP_000259017.1	hypothetical protein	Antitoxin
FP511_RS01415	240025..240315	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
FP511_RS01420	240417..240824	+	408	WP_000749954.1	hypothetical protein	-
FP511_RS01425	240824..241000	+	177	WP_001868321.1	hypothetical protein	-
FP511_RS01430	241036..241383	+	348	WP_123948016.1	hypothetical protein	-
FP511_RS01435	241356..242036	+	681	WP_001865565.1	hypothetical protein	-
FP511_RS01440	242021..242407	+	387	WP_000259069.1	hypothetical protein	-
FP511_RS01445	242441..242722	+	282	WP_000052406.1	hypothetical protein	-
FP511_RS01450	243565..244425	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	230937..239792	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T134824 WP_000384859.1 NZ_CP042001:c239241-238906 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T134824 NZ_CP042001:c239241-238906 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT134824 WP_000259017.1 NZ_CP042001:c239518-239231 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT134824 NZ_CP042001:c239518-239231 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6