Detailed information of TA system TA134823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2045020..2045644
• Replicon: chromosome
• Accession: NZ_CP042000
• Organism: Streptococcus agalactiae strain GBS19

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: FP510_RS10275
• Protein ID: WP_000253103.1
• Coordinates: 2045020..2045367 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: FP510_RS10280
• Protein ID: WP_000543070.1
• Coordinates: 2045357..2045644 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP510_RS10255	2040735..2041091	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
FP510_RS10260	2041158..2043476	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
FP510_RS10265	2043615..2044154	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
FP510_RS10270	2044240..2044536	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
FP510_RS10275	2045020..2045367	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FP510_RS10280	2045357..2045644	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FP510_RS10285	2045713..2046090	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
FP510_RS10290	2046065..2046217	-	153	Protein_1956	DUF1492 domain-containing protein	-
FP510_RS10295	2046224..2046712	-	489	WP_000891151.1	hypothetical protein	-
FP510_RS10300	2046785..2047342	-	558	WP_001258765.1	hypothetical protein	-
FP510_RS10305	2047500..2047673	-	174	WP_000694573.1	hypothetical protein	-
FP510_RS10310	2047670..2047927	-	258	WP_001069293.1	hypothetical protein	-
FP510_RS10315	2048220..2049614	-	1395	WP_000656430.1	hypothetical protein	-
FP510_RS10320	2049626..2050483	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2033961..2073820	39859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T134823 WP_000253103.1 NZ_CP042000:c2045367-2045020 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T134823 NZ_CP042000:c2045367-2045020 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT134823 WP_000543070.1 NZ_CP042000:c2045644-2045357 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT134823 NZ_CP042000:c2045644-2045357 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5