Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 239183..239795 Replicon chromosome
Accession NZ_CP042000
Organism Streptococcus agalactiae strain GBS19

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag FP510_RS01410 Protein ID WP_000384858.1
Coordinates 239183..239518 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag FP510_RS01415 Protein ID WP_000255538.1
Coordinates 239508..239795 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP510_RS01385 234381..235010 + 630 WP_000591148.1 hypothetical protein -
FP510_RS01390 235323..236198 + 876 WP_000770113.1 hypothetical protein -
FP510_RS01395 236234..236668 + 435 WP_001220479.1 hypothetical protein -
FP510_RS01400 236984..238240 + 1257 WP_000122832.1 plasmid recombination protein -
FP510_RS01405 238408..238878 + 471 WP_000130119.1 hypothetical protein -
FP510_RS01410 239183..239518 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FP510_RS01415 239508..239795 - 288 WP_000255538.1 hypothetical protein Antitoxin
FP510_RS01420 240198..241418 - 1221 WP_000156558.1 tyrosine-type recombinase/integrase -
FP510_RS01425 241479..241739 - 261 WP_001196072.1 helix-turn-helix domain-containing protein -
FP510_RS01430 241751..242497 - 747 WP_000966632.1 hypothetical protein -
FP510_RS01435 242683..243474 - 792 WP_001868842.1 hypothetical protein -
FP510_RS01440 243455..243988 - 534 WP_000680721.1 hypothetical protein -
FP510_RS01445 243988..244326 - 339 WP_001187920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 190965..241523 50558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T134822 WP_000384858.1 NZ_CP042000:c239518-239183 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T134822 NZ_CP042000:c239518-239183 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT134822 WP_000255538.1 NZ_CP042000:c239795-239508 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT134822 NZ_CP042000:c239795-239508 [Streptococcus agalactiae]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References