Detailed information of TA system TA134819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2034910..2035534
• Replicon: chromosome
• Accession: NZ_CP041998
• Organism: Streptococcus agalactiae strain GBS7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: FP508_RS10215
• Protein ID: WP_000253103.1
• Coordinates: 2034910..2035257 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: FP508_RS10220
• Protein ID: WP_000543070.1
• Coordinates: 2035247..2035534 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP508_RS10195	2030625..2030981	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
FP508_RS10200	2031048..2033366	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
FP508_RS10205	2033505..2034044	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
FP508_RS10210	2034130..2034426	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
FP508_RS10215	2034910..2035257	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FP508_RS10220	2035247..2035534	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FP508_RS10225	2035603..2035980	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
FP508_RS10230	2035955..2036107	-	153	Protein_1944	DUF1492 domain-containing protein	-
FP508_RS10235	2036114..2036602	-	489	WP_000891151.1	hypothetical protein	-
FP508_RS10240	2036675..2037232	-	558	WP_001258765.1	hypothetical protein	-
FP508_RS10245	2037390..2037563	-	174	WP_000694573.1	hypothetical protein	-
FP508_RS10250	2037560..2037817	-	258	WP_001069293.1	hypothetical protein	-
FP508_RS10255	2038088..2039482	-	1395	WP_000656430.1	hypothetical protein	-
FP508_RS10260	2039494..2040351	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2029748..2063688	33940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T134819 WP_000253103.1 NZ_CP041998:c2035257-2034910 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T134819 NZ_CP041998:c2035257-2034910 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT134819 WP_000543070.1 NZ_CP041998:c2035534-2035247 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT134819 NZ_CP041998:c2035534-2035247 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5