Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1473677..1474785 Replicon chromosome
Accession NZ_CP041995
Organism Erysipelothrix rhusiopathiae strain ZJ

Toxin (Protein)


Gene name MNTss Uniprot ID A0A2I4SCC6
Locus tag FPT19_RS07270 Protein ID WP_062810426.1
Coordinates 1473677..1474546 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag FPT19_RS07275 Protein ID WP_002303393.1
Coordinates 1474561..1474785 (-) Length 75 a.a.

Genomic Context

FPT19_RS07230FPT19_RS07240FPT19_RS07250FPT19_RS07255FPT19_RS07260FPT19_RS07265FPT19_RS07270FPT19_RS07275FPT19_RS07280FPT19_RS07285FPT19_RS07290FPT19_RS07295
Location: 1469367..1469774 (408 bp)
Type: Others
Protein ID: WP_072387101.1
Location: 1469747..1470319 (573 bp)
Type: Others
Protein ID: WP_001079938.1
Location: 1470595..1471389 (795 bp)
Type: Others
Protein ID: WP_001096887.1
Location: 1471482..1472024 (543 bp)
Type: Others
Protein ID: WP_000627290.1
Location: 1472021..1472929 (909 bp)
Type: Others
Protein ID: WP_001255864.1
Location: 1472962..1473696 (735 bp)
Type: Others
Protein ID: WP_000662263.1
Location: 1473677..1474546 (870 bp)
Type: Toxin
Protein ID: WP_062810426.1
Location: 1474561..1474785 (225 bp)
Type: Antitoxin
Protein ID: WP_002303393.1
Location: 1474928..1475749 (822 bp)
Type: Others
Protein ID: Protein_1387
Location: 1476437..1477240 (804 bp)
Type: Others
Protein ID: WP_002294514.1
Location: 1477294..1478778 (1485 bp)
Type: Others
Protein ID: WP_002294513.1
Location: 1479221..1479784 (564 bp)
Type: Others
Protein ID: Protein_1390
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPT19_RS072301469367..1469774-408WP_072387101.1WYL domain-containing protein-
FPT19_RS072401469747..1470319-573WP_001079938.1HTH domain-containing protein-
FPT19_RS072501470595..1471389-795WP_001096887.1aminoglycoside O-phosphotransferase APH(3')-IIIa-
FPT19_RS072551471482..1472024-543WP_000627290.1streptothricin N-acetyltransferase Sat4-
FPT19_RS072601472021..1472929-909WP_001255864.1aminoglycoside nucleotidyltransferase ANT(6)-Ia-
FPT19_RS072651472962..1473696-735WP_000662263.1class I SAM-dependent methyltransferase-
FPT19_RS072701473677..1474546-870WP_062810426.1nucleotidyltransferase domain-containing proteinToxin
FPT19_RS072751474561..1474785-225WP_002303393.1helix-turn-helix transcriptional regulatorAntitoxin
FPT19_RS072801474928..1475749-822Protein_1387recombinase zinc beta ribbon domain-containing protein-
FPT19_RS072851476437..1477240-804WP_002294514.1lincosamide nucleotidyltransferase Lnu(B)-
FPT19_RS072901477294..1478778-1485WP_002294513.1ABC-F type ribosomal protection protein Lsa(E)-
FPT19_RS072951479221..1479784-564Protein_1390recombinase zinc beta ribbon domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32793.31 Da        Isoelectric Point: 4.6575

>T134778 WP_062810426.1 NZ_CP041995:c1474546-1473677 [Erysipelothrix rhusiopathiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T134778 NZ_CP041995:c1474546-1473677 [Erysipelothrix rhusiopathiae]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATTGTATTAGGGGGCTC
ACGTGCAAGAAGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAGTTGGATGATGAGAATAGAAACAACCTTGTTGTACCTCCCGGAGCGTGGGGTGATTGG
GTTAATGGCGGTGGATGGTTAGTTATAAACGGGTGTCATGTTGACTTGATATTACGTGATATAAAACGGGTGGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCTATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGCAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGACATGACCGAGAAACTTTATAATGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT134778 WP_002303393.1 NZ_CP041995:c1474785-1474561 [Erysipelothrix rhusiopathiae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp

>AT134778 NZ_CP041995:c1474785-1474561 [Erysipelothrix rhusiopathiae]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCTATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGATGAAATAAAAATATCTAACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2I4SCC6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1M5SHM7

References