Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1999867..2000350 Replicon chromosome
Accession NZ_CP041994
Organism Streptococcus suis strain INT-01

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag FPT06_RS10115 Protein ID WP_009910443.1
Coordinates 2000090..2000350 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag FPT06_RS10110 Protein ID WP_012775256.1
Coordinates 1999867..2000088 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPT06_RS10080 1994869..1995504 + 636 WP_002935723.1 phosphoserine phosphatase SerB -
FPT06_RS10085 1995535..1996185 - 651 WP_002935722.1 HAD family hydrolase -
FPT06_RS10090 1996293..1997420 + 1128 WP_002935718.1 glycerate kinase -
FPT06_RS10095 1997411..1997638 + 228 WP_002935708.1 hypothetical protein -
FPT06_RS10100 1997648..1998100 - 453 WP_013730449.1 DUF1694 domain-containing protein -
FPT06_RS10105 1998250..1999557 + 1308 WP_002935704.1 phosphopyruvate hydratase -
FPT06_RS10110 1999867..2000088 + 222 WP_012775256.1 hypothetical protein Antitoxin
FPT06_RS10115 2000090..2000350 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPT06_RS10120 2000517..2001158 + 642 WP_002935700.1 HAD family hydrolase -
FPT06_RS10125 2001191..2001376 - 186 WP_002935693.1 hypothetical protein -
FPT06_RS10130 2001440..2002444 - 1005 WP_009910438.1 lactonase family protein -
FPT06_RS10135 2002580..2003746 + 1167 WP_002935690.1 AI-2E family transporter -
FPT06_RS10140 2003736..2004965 + 1230 WP_009910437.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T134777 WP_009910443.1 NZ_CP041994:2000090-2000350 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T134777 NZ_CP041994:2000090-2000350 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT134777 WP_012775256.1 NZ_CP041994:1999867-2000088 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT134777 NZ_CP041994:1999867-2000088 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References